5H-Cyclohepta[b]pyridine-3-carboxylic acid, 2-[[(3,4-dimethoxyphenyl)methyl]amino]-8-(2-ethoxy-2-oxoethylidene)-6, 7,8,9-tetrahydro-9-oxo-, ethyl ester

Base Information

• Chemical Name: 5H-Cyclohepta[b]pyridine-3-carboxylic acid, 2-[[(3,4-dimethoxyphenyl)methyl]amino]-8-(2-ethoxy-2-oxoethylidene)-6, 7,8,9-tetrahydro-9-oxo-, ethyl ester
• CAS No.: 138722-55-1
• Molecular Formula: C26H30N2O7
• Molecular Weight: 482.533
• Mol file: 138722-55-1.mol

Synonyms:

Chemical Property of 5H-Cyclohepta[b]pyridine-3-carboxylic acid, 2-[[(3,4-dimethoxyphenyl)methyl]amino]-8-(2-ethoxy-2-oxoethylidene)-6, 7,8,9-tetrahydro-9-oxo-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5H-Cyclohepta[b]pyridine-3-carboxylic acid, 2-[[(3,4-dimethoxyphenyl)methyl]amino]-8-(2-ethoxy-2-oxoethylidene)-6, 7,8,9-tetrahydro-9-oxo-, ethyl ester

There total 2 articles about 5H-Cyclohepta[b]pyridine-3-carboxylic acid, 2-[[(3,4-dimethoxyphenyl)methyl]amino]-8-(2-ethoxy-2-oxoethylidene)-6, 7,8,9-tetrahydro-9-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5H-cycloheptapyridine-3-carboxylic acid, 2-<<(3,4-dimethoxyphenyl)methyl>amino>-6,7,8,9-tetrahydro-9-oxo-, ethyl ester (138722-53-9) → 2-(3,4-Dimethoxy-benzylamino)-8-[1-ethoxycarbonyl-meth-(Z)-ylidene]-9-oxo-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine-3-carboxylic acid ethyl ester (138722-55-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran

2: 2.) HCl / 1.) irradiation

With hydrogenchloride; In tetrahydrofuran;

DOI:10.1021/ja00031a065

Reference yield:

glyoxylic acid ethyl ester (924-44-7) + 5H-cycloheptapyridine-3-carboxylic acid, 2-<<(3,4-dimethoxyphenyl)methyl>amino>-6,7-dihydro-9-(1-pyrrolidinyl), ethyl ester (138722-54-0) → 2-(3,4-Dimethoxy-benzylamino)-8-[1-ethoxycarbonyl-meth-(Z)-ylidene]-9-oxo-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine-3-carboxylic acid ethyl ester (138722-55-1)

Guidance literature:

With hydrogenchloride; Yield given. Multistep reaction; 1.) irradiation;

DOI:10.1021/ja00031a065

Reference yield:

2-(3,4-Dimethoxy-benzylamino)-8-[1-ethoxycarbonyl-meth-(Z)-ylidene]-9-oxo-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine-3-carboxylic acid ethyl ester (138722-55-1) → bispyrido<3',2':6,7>cyclohepta<1,2-b:2',1'-e>pyridine-3,8,13-tricarboxylic acid, 2,14-bis<<(3,4-dimethoxyphenyl)methyl>amino>-5,6,7,9,10,11-hexahydro-, triethyl ester (154796-24-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) HCl

2: 50 percent / NH₄OAc, HOAc

With hydrogenchloride; ammonium acetate; acetic acid;

DOI:10.1021/ja00031a065

upstream raw materials:

glyoxylic acid ethyl ester

5H-cycloheptapyridine-3-carboxylic acid, 2-<<(3,4-dimethoxyphenyl)methyl>amino>-6,7-dihydro-9-(1-pyrrolidinyl), ethyl ester

5H-cycloheptapyridine-3-carboxylic acid, 2-<<(3,4-dimethoxyphenyl)methyl>amino>-6,7,8,9-tetrahydro-9-oxo-, ethyl ester

Downstream raw materials:

α-bis-<2-<<(3,4-dimethoxyphenyl)methyl>amino>-3-(ethoxycarbonyl)-6,7,8,9-tetrahydro-9-oxo-8-(5H)-pyridocycloheptyl>acetic acid, ethyl ester

bispyrido<3',2':6,7>cyclohepta<1,2-b:2',1'-e>pyridine-3,8,13-tricarboxylic acid, 2,14-bis<<(3,4-dimethoxyphenyl)methyl>amino>-5,6,7,9,10,11-hexahydro-, triethyl ester