4-Hydroxy-2,2-dimethyl-3,4-dihydropyrano[3,2-g]chromen-8-one

Base Information

• Chemical Name: 4-Hydroxy-2,2-dimethyl-3,4-dihydropyrano[3,2-g]chromen-8-one
• CAS No.: 16498-71-8
• Molecular Formula: C₁₄H₁₄O₄
• Molecular Weight: 246.263
• DSSTox Substance ID: DTXSID401142427
• Nikkaji Number: J102.872C
• ChEMBL ID: CHEMBL480291
• Mol file: 16498-71-8.mol

Synonyms:16498-71-8;4-hydroxy-2,2-dimethyl-3,4-dihydropyrano[3,2-g]chromen-8-one;2H,6H-Benzo[1,2-b:5,4-b']dipyran-2-one, 7,8-dihydro-6-hydroxy-8,8-dimethyl-;8,8-Dimethyl-6-hydroxy-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b/']dipyran-2-one;CHEMBL480291;DTXSID401142427;6-Hydroxy-8,8-dimethyl-7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-2-one #;7,8-Dihydro-6-hydroxy-8,8-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-2-one

Chemical Property of 4-Hydroxy-2,2-dimethyl-3,4-dihydropyrano[3,2-g]chromen-8-one

Chemical Property:

• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 246.08920892
• Heavy Atom Count: 18
• Complexity: 387

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1(CC(C2=C(O1)C=C3C(=C2)C=CC(=O)O3)O)C

Technology Process of 4-Hydroxy-2,2-dimethyl-3,4-dihydropyrano[3,2-g]chromen-8-one

There total 2 articles about 4-Hydroxy-2,2-dimethyl-3,4-dihydropyrano[3,2-g]chromen-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(6S,7R)-7-Bromo-6-hydroxy-8,8-dimethyl-7,8-dihydro-6H-pyrano[3,2-g]chromen-2-one → 6-Hydroxy-8,8-dimethyl-7,8-dihydro-6H-pyrano[3,2-g]chromen-2-one (16498-71-8)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; Heating;

DOI:10.1021/np9800295

Reference yield:

xanthyletin (553-19-5) → 6-Hydroxy-8,8-dimethyl-7,8-dihydro-6H-pyrano[3,2-g]chromen-2-one (16498-71-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / N-bromosuccinimide / tetrahydrofuran; H₂O

2: 71 percent / AIBN, Bu₃SnH / toluene / Heating

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In tetrahydrofuran; water; toluene;

DOI:10.1021/np9800295

Reference yield: 68.0%

benzoic acid anhydride (93-97-0) + 6-Hydroxy-8,8-dimethyl-7,8-dihydro-6H-pyrano[3,2-g]chromen-2-one (16498-71-8) → Benzoic acid 2,2-dimethyl-8-oxo-3,4-dihydro-2H,8H-pyrano[3,2-g]chromen-4-yl ester

Guidance literature:

With pyridine; Ambient temperature;

DOI:10.1021/np9800295

upstream raw materials:

xanthyletin