Technology Process of 4-[7-(4-Fluoro-phenyl)-benzothiazol-2-yl]-thiophene-2-sulfonic acid amide
There total 6 articles about 4-[7-(4-Fluoro-phenyl)-benzothiazol-2-yl]-thiophene-2-sulfonic acid amide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: bromine; acetic acid
2: sodium nitrite; sulfuric acid; hypophosphorous acid
3: [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium carbonate / water; toluene; ethanol
4: n-butyllithium; carbon tetrabromide
5: [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium carbonate / water; toluene; ethanol
6: chlorosulfonic acid / chloroform
7: trichlorophosphate; phosphorus pentachloride
8: ammonia / methanol
With
chlorosulfonic acid; n-butyllithium; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); carbon tetrabromide; phosphorus pentachloride; sulfuric acid; ammonia; bromine; hypophosphorous acid; sodium carbonate; acetic acid; sodium nitrite; trichlorophosphate;
In
methanol; ethanol; chloroform; water; toluene;
2: |Sandmeyer Reaction / 3: |Suzuki-Miyaura Coupling / 5: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2012.07.068
- Guidance literature:
-
Multi-step reaction with 3 steps
1: chlorosulfonic acid / chloroform
2: trichlorophosphate; phosphorus pentachloride
3: ammonia / methanol
With
chlorosulfonic acid; phosphorus pentachloride; ammonia; trichlorophosphate;
In
methanol; chloroform;
DOI:10.1016/j.bmcl.2012.07.068
- Guidance literature:
-
Multi-step reaction with 5 steps
1: n-butyllithium; carbon tetrabromide
2: [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium carbonate / water; toluene; ethanol
3: chlorosulfonic acid / chloroform
4: trichlorophosphate; phosphorus pentachloride
5: ammonia / methanol
With
chlorosulfonic acid; n-butyllithium; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); carbon tetrabromide; phosphorus pentachloride; ammonia; sodium carbonate; trichlorophosphate;
In
methanol; ethanol; chloroform; water; toluene;
2: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2012.07.068