benzyl (R)-2-{(2S,3S)-1-[((S)-1-{3-[(2R,4S)-5-methoxy-4-methyl-5-oxo-1-phenylpentan-2-ylcarbamoyl]phenoxy}-3-methylbutan-2-yl)methylamino]-3-methyl-1-oxopentan-2-ylcarbamoyl}piperidine-1-carboxylate

Base Information

Chemical Name:benzyl (R)-2-{(2S,3S)-1-[((S)-1-{3-[(2R,4S)-5-methoxy-4-methyl-5-oxo-1-phenylpentan-2-ylcarbamoyl]phenoxy}-3-methylbutan-2-yl)methylamino]-3-methyl-1-oxopentan-2-ylcarbamoyl}piperidine-1-carboxylate
CAS No.:1311415-83-4
Molecular Formula:C₄₆H₆₂N₄O₈
Molecular Weight:799.02
Hs Code.:

benzyl (R)-2-{(2S,3S)-1-[((S)-1-{3-[(2R,4S)-5-methoxy-4-methyl-5-oxo-1-phenylpentan-2-ylcarbamoyl]phenoxy}-3-methylbutan-2-yl)methylamino]-3-methyl-1-oxopentan-2-ylcarbamoyl}piperidine-1-carboxylate

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Chemical Property of benzyl (R)-2-{(2S,3S)-1-[((S)-1-{3-[(2R,4S)-5-methoxy-4-methyl-5-oxo-1-phenylpentan-2-ylcarbamoyl]phenoxy}-3-methylbutan-2-yl)methylamino]-3-methyl-1-oxopentan-2-ylcarbamoyl}piperidine-1-carboxylate

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Technology Process of benzyl (R)-2-{(2S,3S)-1-[((S)-1-{3-[(2R,4S)-5-methoxy-4-methyl-5-oxo-1-phenylpentan-2-ylcarbamoyl]phenoxy}-3-methylbutan-2-yl)methylamino]-3-methyl-1-oxopentan-2-ylcarbamoyl}piperidine-1-carboxylate

There total 9 articles about benzyl (R)-2-{(2S,3S)-1-[((S)-1-{3-[(2R,4S)-5-methoxy-4-methyl-5-oxo-1-phenylpentan-2-ylcarbamoyl]phenoxy}-3-methylbutan-2-yl)methylamino]-3-methyl-1-oxopentan-2-ylcarbamoyl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,4R)-methyl 4-amino-2-methyl-5-phenylpentanoate hydrochloride

: C₃₃H₄₅N₃O₇

: 1311415-83-4
benzyl (R)-2-{(2S,3S)-1-[((S)-1-{3-[(2R,4S)-5-methoxy-4-methyl-5-oxo-1-phenylpentan-2-ylcarbamoyl]phenoxy}-3-methylbutan-2-yl)methylamino]-3-methyl-1-oxopentan-2-ylcarbamoyl}piperidine-1-carboxylate

Guidance literature:: C₃₃H₄₅N₃O₇; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -20 ℃; for 0.333333h; Inert atmosphere;

methyl (2S,4R)-4-amino-2-methyl-5-phenylpentanoate hydrochloride; In tetrahydrofuran; at -20 - 20 ℃; Inert atmosphere;
DOI:10.1002/ejoc.201100155

Reference yield:

: 1311415-72-1
methyl (S)-3-[2-(tert-butoxycarbonylamino)-3-methylbutoxy]benzoate

: 1311415-83-4
benzyl (R)-2-{(2S,3S)-1-[((S)-1-{3-[(2R,4S)-5-methoxy-4-methyl-5-oxo-1-phenylpentan-2-ylcarbamoyl]phenoxy}-3-methylbutan-2-yl)methylamino]-3-methyl-1-oxopentan-2-ylcarbamoyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 21 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 0 °C

3.1: 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / -10 - 20 °C / Inert atmosphere

4.1: 10% palladium on carbon; hydrogen / methanol / 1 h

5.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / -20 °C / Inert atmosphere

5.2: -20 - 20 °C / Inert atmosphere

6.1: sodium hydroxide / methanol; water / 3 h / 60 °C

6.2: pH 1

7.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / -20 °C / Inert atmosphere

7.2: -20 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; 10% palladium on carbon; hydrogen; 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201100155

Reference yield:

: 1311415-73-2
methyl (S)-3-[2-[(tert-butoxycarbonyl)methylamino]-3-methylbutoxy]benzoate

: 1311415-83-4
benzyl (R)-2-{(2S,3S)-1-[((S)-1-{3-[(2R,4S)-5-methoxy-4-methyl-5-oxo-1-phenylpentan-2-ylcarbamoyl]phenoxy}-3-methylbutan-2-yl)methylamino]-3-methyl-1-oxopentan-2-ylcarbamoyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h / 0 °C

2.1: 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / -10 - 20 °C / Inert atmosphere

3.1: 10% palladium on carbon; hydrogen / methanol / 1 h

4.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / -20 °C / Inert atmosphere

4.2: -20 - 20 °C / Inert atmosphere

5.1: sodium hydroxide / methanol; water / 3 h / 60 °C

5.2: pH 1

6.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / -20 °C / Inert atmosphere

6.2: -20 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; 10% palladium on carbon; hydrogen; 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1002/ejoc.201100155