C₂₈H₂₄⁽²⁾H₃N₃O₃

Base Information

• Chemical Name: C₂₈H₂₄⁽²⁾H₃N₃O₃
• CAS No.: 1026501-87-0
• Molecular Formula: C₂₈H₂₇N₃O₃
• Molecular Weight: 456.517
• Mol file: 1026501-87-0.mol

Synonyms:

Chemical Property of C₂₈H₂₄⁽²⁾H₃N₃O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₂₄⁽²⁾H₃N₃O₃

There total 12 articles about C₂₈H₂₄⁽²⁾H₃N₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

10-(4-tert-butylphenyl)-3-(2-carboxyphenyl)[5-2H]pyrimido[4,5-b]quinoline-2,4-(3H,10H)-dione → C28H24(2)H3N3O3 (1026501-87-0)

Guidance literature:

With sodium borodeuteride; boron trifluoride diethyl etherate; In tetrahydrofuran; for 1h; Ambient temperature;

DOI:10.1021/jo961799t

Reference yield:

2-fluoro-benzoic acid ethyl ester (443-26-5) → C28H24(2)H3N3O3 (1026501-87-0)

Guidance literature:

Multi-step reaction with 5 steps

1: LiAlD₄ / diethyl ether

2: pyridinium chlorochromate / CH₂Cl₂

3: dimethylformamide / 6 h / 100 °C

4: H₂SO₄ / H₂O / 5 h / 130 °C

5: NaBD₄, BF₃*Et₂O / tetrahydrofuran / 1 h / Ambient temperature

With lithium aluminium deuteride; sodium borodeuteride; sulfuric acid; boron trifluoride diethyl etherate; pyridinium chlorochromate; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jo961799t

Reference yield:

4-tert-Butylaniline (769-92-6) → C28H24(2)H3N3O3 (1026501-87-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 76 percent / butan-1-ol / 3 h / Heating

2: dimethylformamide / 6 h / 100 °C

3: H₂SO₄ / H₂O / 5 h / 130 °C

4: NaBD₄, BF₃*Et₂O / tetrahydrofuran / 1 h / Ambient temperature

With sodium borodeuteride; sulfuric acid; boron trifluoride diethyl etherate; In tetrahydrofuran; water; N,N-dimethyl-formamide; butan-1-ol;

DOI:10.1021/jo961799t

upstream raw materials:

2-fluoro-benzoic acid ethyl ester

4-tert-Butylaniline

1-<2-(trifluoromethyl)phenyl>urea

2-fluoro-<α,α-²H2>benzyl alcohol

Downstream raw materials:

3-(2-{[(tert-butyldimethylsilyl)oxy][²H₂]methyl}phenyl)-10-(4-tert-butylphenyl)[5-²H]pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione

Refernces