N-(4-difluoromethyl-3-piperidin-4-yl-benzyl)-2,2,2-trifluoro-acetamide hydrochloride

Base Information

Chemical Name:N-(4-difluoromethyl-3-piperidin-4-yl-benzyl)-2,2,2-trifluoro-acetamide hydrochloride
CAS No.:1313041-78-9
Molecular Formula:C₁₅H₁₇F₅N₂O*ClH
Molecular Weight:372.766
Hs Code.:

Synonyms:

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Chemical Property of N-(4-difluoromethyl-3-piperidin-4-yl-benzyl)-2,2,2-trifluoro-acetamide hydrochloride

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Technology Process of N-(4-difluoromethyl-3-piperidin-4-yl-benzyl)-2,2,2-trifluoro-acetamide hydrochloride

There total 5 articles about N-(4-difluoromethyl-3-piperidin-4-yl-benzyl)-2,2,2-trifluoro-acetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 345953-43-7
4-(bromomethyl)-2-bromobenzaldehyde

: 1313041-78-9
N-(4-difluoromethyl-3-piperidin-4-yl-benzyl)-2,2,2-trifluoro-acetamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium azide / N,N-dimethyl-formamide / 20 °C

2.1: 2,2-difluoro-1,3-dimethyl-imidazolidine / acetonitrile / 84 °C

3.1: triphenylphosphine; water / tetrahydrofuran / 20 °C

3.2: 0 °C

3.3: pH 10

4.1: sodium hydrogencarbonate / 0.33 h / Inert atmosphere

4.2: 22 h / 85 °C

5.1: acetic acid butyl ester / 4 h / 0 °C

5.2: 0.33 h

6.1: hydrogen / platinum on carbon / methanol / 24 h / 2585.81 - 3102.97 Torr

With sodium azide; water; hydrogen; sodium hydrogencarbonate; triphenylphosphine; 2,2-difluoro-1,3-dimethyl-imidazolidine; platinum on carbon; In tetrahydrofuran; methanol; acetic acid butyl ester; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1313041-76-7
4-difluoromethyl-3-pyridin-4-yl-benzylamine

: 1313041-78-9
N-(4-difluoromethyl-3-piperidin-4-yl-benzyl)-2,2,2-trifluoro-acetamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid butyl ester / 4 h / 0 °C

1.2: 0.33 h

2.1: hydrogen / platinum on carbon / methanol / 24 h / 2585.81 - 3102.97 Torr

With hydrogen; platinum on carbon; In methanol; acetic acid butyl ester;

Reference yield:

: 1313041-73-4
4-(azidomethyl)-2-bromobenzaldehyde

: 1313041-78-9
N-(4-difluoromethyl-3-piperidin-4-yl-benzyl)-2,2,2-trifluoro-acetamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2,2-difluoro-1,3-dimethyl-imidazolidine / acetonitrile / 84 °C

2.1: triphenylphosphine; water / tetrahydrofuran / 20 °C

2.2: 0 °C

2.3: pH 10

3.1: sodium hydrogencarbonate / 0.33 h / Inert atmosphere

3.2: 22 h / 85 °C

4.1: acetic acid butyl ester / 4 h / 0 °C

4.2: 0.33 h

5.1: hydrogen / platinum on carbon / methanol / 24 h / 2585.81 - 3102.97 Torr

With water; hydrogen; sodium hydrogencarbonate; triphenylphosphine; 2,2-difluoro-1,3-dimethyl-imidazolidine; platinum on carbon; In tetrahydrofuran; methanol; acetic acid butyl ester; acetonitrile;