Technology Process of 1-(4-tert-butylphenyl)-1,2,3,4-tetrahydroquinoline-6-carbaldehyde
There total 3 articles about 1-(4-tert-butylphenyl)-1,2,3,4-tetrahydroquinoline-6-carbaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N,N-dimethyl-formamide;
With
trichlorophosphate;
for 0.5h;
Inert atmosphere;
Cooling with ice;
1-(4-(tert-butyl)phenyl)-1,2,3,4-tetrahydroquinoline;
at 90 ℃;
for 12h;
Inert atmosphere;
DOI:10.1039/c0jm03109g
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate / toluene / 0.25 h / Inert atmosphere; Heating
1.2: 24 h / Inert atmosphere; Heating
2.1: trichlorophosphate / 0.5 h / Inert atmosphere; Cooling with ice
2.2: 12 h / 90 °C / Inert atmosphere
With
1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; trichlorophosphate;
In
toluene;
1.1: Buchwald-Hartwig coupling / 1.2: Buchwald-Hartwig coupling / 2.1: Vilsmeier-Haack reaction / 2.2: Vilsmeier-Haack reaction;
DOI:10.1039/c0jm03109g
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate / toluene / 0.25 h / Inert atmosphere; Heating
1.2: 24 h / Inert atmosphere; Heating
2.1: trichlorophosphate / 0.5 h / Inert atmosphere; Cooling with ice
2.2: 12 h / 90 °C / Inert atmosphere
With
1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; trichlorophosphate;
In
toluene;
1.1: Buchwald-Hartwig coupling / 1.2: Buchwald-Hartwig coupling / 2.1: Vilsmeier-Haack reaction / 2.2: Vilsmeier-Haack reaction;
DOI:10.1039/c0jm03109g
