Technology Process of C21H18ClNO2
There total 5 articles about C21H18ClNO2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-(naphthalen-2-yl)-N-propylbenzamide;
With
trimethylsilyl trifluoromethanesulfonate; triethylamine;
In
diethyl ether;
at 20 ℃;
for 16h;
Inert atmosphere;
phosgene;
In
toluene;
at 0 - 20 ℃;
for 4h;
Inert atmosphere;
DOI:10.1021/jm401948b
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C
2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / toluene; ethanol / 80 °C
3.1: triethylamine; trimethylsilyl trifluoromethanesulfonate / diethyl ether / 16 h / 20 °C / Inert atmosphere
3.2: 4 h / 0 - 20 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); trimethylsilyl trifluoromethanesulfonate; sodium carbonate; triethylamine;
In
diethyl ether; ethanol; dichloromethane; toluene;
2.1: |Suzuki Coupling;
DOI:10.1021/jm401948b
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: thionyl chloride / toluene / Reflux
2.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C
3.1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / toluene; ethanol / 80 °C
4.1: triethylamine; trimethylsilyl trifluoromethanesulfonate / diethyl ether / 16 h / 20 °C / Inert atmosphere
4.2: 4 h / 0 - 20 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); thionyl chloride; trimethylsilyl trifluoromethanesulfonate; sodium carbonate; triethylamine;
In
diethyl ether; ethanol; dichloromethane; toluene;
3.1: |Suzuki Coupling;
DOI:10.1021/jm401948b
