Technology Process of 5H-Cyclohepta[b]pyridine-8-acetic acid,
2-[[(3,4-dimethoxyphenyl)ethyl]amino]-a-[2-[[(3,4-dimethoxyphenyl)meth
yl]amino]-3-(ethoxycarbonyl)-6,7,8,9-tetrahydro-9-oxo-5H-cyclohepta[b]
pyridin-8-yl]-3-(ethoxycarbonyl)-6,7,8,9-tetrahydro-9-oxo-
There total 12 articles about 5H-Cyclohepta[b]pyridine-8-acetic acid,
2-[[(3,4-dimethoxyphenyl)ethyl]amino]-a-[2-[[(3,4-dimethoxyphenyl)meth
yl]amino]-3-(ethoxycarbonyl)-6,7,8,9-tetrahydro-9-oxo-5H-cyclohepta[b]
pyridin-8-yl]-3-(ethoxycarbonyl)-6,7,8,9-tetrahydro-9-oxo- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 100 percent / TsOH / tetrahydrofuran / 50 °C
2: 2.) HCl / 1.) THF, from -78 deg C to RT, 36 h, 2.) THF, 6 h
3: 2.) HCl / 1.) THF, reflux, 24 h, 2.) THF, overnight
With
hydrogenchloride; toluene-4-sulfonic acid;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) OsO4, 2.) NaIO4 / 1.) H2O, THF, t-BuOH, 10 min, 2.) H2O, THF, t-BuOH, 30 h
2: 100 percent / TsOH / tetrahydrofuran / 50 °C
3: 2.) HCl / 1.) THF, from -78 deg C to RT, 36 h, 2.) THF, 6 h
4: 2.) HCl / 1.) THF, reflux, 24 h, 2.) THF, overnight
With
hydrogenchloride; sodium periodate; osmium(VIII) oxide; toluene-4-sulfonic acid;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 94 percent / dimethylformamide / 60 h / Heating
2: 97 percent / 2 N aq. HCl / 2.5 h
3: 61 percent / tetrahydrofuran / 20 h / Ambient temperature
4: 1.) OsO4, 2.) NaIO4 / 1.) H2O, THF, t-BuOH, 10 min, 2.) H2O, THF, t-BuOH, 30 h
5: 100 percent / TsOH / tetrahydrofuran / 50 °C
6: 2.) HCl / 1.) THF, reflux, 24 h, 2.) THF, overnight
With
hydrogenchloride; sodium periodate; osmium(VIII) oxide; toluene-4-sulfonic acid;
In
tetrahydrofuran; N,N-dimethyl-formamide;
