benzyl N-(((S)-4-amino-1-(2-(N-(tert-butoxycarbonyl)-O-(tert-butyl)-L-seryl)hydrazinyl)-1,4-dioxobutan-2-yl)carbamoyl)-O-(tert-butyl)-L-threoninate

Base Information

Chemical Name:benzyl N-(((S)-4-amino-1-(2-(N-(tert-butoxycarbonyl)-O-(tert-butyl)-L-seryl)hydrazinyl)-1,4-dioxobutan-2-yl)carbamoyl)-O-(tert-butyl)-L-threoninate
CAS No.:1454708-67-8
Molecular Formula:C₃₂H₅₂N₆O₁₀
Molecular Weight:680.799
Hs Code.:

benzyl N-(((S)-4-amino-1-(2-(N-(tert-butoxycarbonyl)-O-(tert-butyl)-L-seryl)hydrazinyl)-1,4-dioxobutan-2-yl)carbamoyl)-O-(tert-butyl)-L-threoninate

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Chemical Property of benzyl N-(((S)-4-amino-1-(2-(N-(tert-butoxycarbonyl)-O-(tert-butyl)-L-seryl)hydrazinyl)-1,4-dioxobutan-2-yl)carbamoyl)-O-(tert-butyl)-L-threoninate

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Technology Process of benzyl N-(((S)-4-amino-1-(2-(N-(tert-butoxycarbonyl)-O-(tert-butyl)-L-seryl)hydrazinyl)-1,4-dioxobutan-2-yl)carbamoyl)-O-(tert-butyl)-L-threoninate

There total 9 articles about benzyl N-(((S)-4-amino-1-(2-(N-(tert-butoxycarbonyl)-O-(tert-butyl)-L-seryl)hydrazinyl)-1,4-dioxobutan-2-yl)carbamoyl)-O-(tert-butyl)-L-threoninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13734-38-8,20887-86-9
N-(t-butyloxycarbonyl)-O-(t-butyl)-L-Serine

: 1454708-67-8
benzyl N-(((S)-4-amino-1-(2-(N-(tert-butoxycarbonyl)-O-(tert-butyl)-L-seryl)hydrazinyl)-1,4-dioxobutan-2-yl)carbamoyl)-O-(tert-butyl)-L-threoninate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / 5 h / 20 °C

2.1: hydrazine hydrate / methanol / 12 h / 20 °C

3.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h / 20 °C

3.2: 12 h / 20 °C

4.1: hydrogen; palladium(II) hydroxide / methanol / 8 h / Inert atmosphere

5.1: triethylamine / tetrahydrofuran / 20 h / 20 °C

With hydrogen; palladium(II) hydroxide; potassium carbonate; benzotriazol-1-ol; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1454708-65-6
tert-butyl ((5S,10S)-5-(2-amino-2-oxoethyl)-13,13-dimethyl-3,6,9-trioxo-1-phenyl-2,12-dioxa-4,7,8-triazatetradecan-10-yl)carbamate

: 1454708-67-8
benzyl N-(((S)-4-amino-1-(2-(N-(tert-butoxycarbonyl)-O-(tert-butyl)-L-seryl)hydrazinyl)-1,4-dioxobutan-2-yl)carbamoyl)-O-(tert-butyl)-L-threoninate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium(II) hydroxide / methanol / 8 h / Inert atmosphere

2: triethylamine / tetrahydrofuran / 20 h / 20 °C

With hydrogen; palladium(II) hydroxide; triethylamine; In tetrahydrofuran; methanol;

Reference yield:

: 100-39-0
benzyl bromide

: 1454708-67-8
benzyl N-(((S)-4-amino-1-(2-(N-(tert-butoxycarbonyl)-O-(tert-butyl)-L-seryl)hydrazinyl)-1,4-dioxobutan-2-yl)carbamoyl)-O-(tert-butyl)-L-threoninate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 12.5 h / 0 - 20 °C / Cooling with ice

2: diethylamine / dichloromethane / 1 h / 20 °C

3: triethylamine / dichloromethane / 12 h / 20 °C

4: triethylamine / tetrahydrofuran / 20 h / 20 °C

With caesium carbonate; diethylamine; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;