[9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(3-nitro-[1,2,4]triazol-1-yl)-9H-purin-2-yl]-[(4-methoxy-phenyl)-diphenyl-methyl]-amine

Base Information

• Chemical Name: [9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(3-nitro-[1,2,4]triazol-1-yl)-9H-purin-2-yl]-[(4-methoxy-phenyl)-diphenyl-methyl]-amine
• CAS No.: 93170-46-8
• Molecular Formula: C₄₄H₅₇N₉O₆Si₂
• Molecular Weight: 864.164

Synonyms:

Chemical Property of [9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(3-nitro-[1,2,4]triazol-1-yl)-9H-purin-2-yl]-[(4-methoxy-phenyl)-diphenyl-methyl]-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of [9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(3-nitro-[1,2,4]triazol-1-yl)-9H-purin-2-yl]-[(4-methoxy-phenyl)-diphenyl-methyl]-amine

There total 4 articles about [9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(3-nitro-[1,2,4]triazol-1-yl)-9H-purin-2-yl]-[(4-methoxy-phenyl)-diphenyl-methyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-9H-purin-6-ol (111484-37-8) + 3-nitro-1,2,4-triazole (24807-55-4) → [9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(3-nitro-[1,2,4]triazol-1-yl)-9H-purin-2-yl]-[(4-methoxy-phenyl)-diphenyl-methyl]-amine (93170-46-8)

Guidance literature:

With 2-chlorophenyl dichlorophosphate; In pyridine;

DOI:10.1016/S0040-4039(01)91006-8

Reference yield:

3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine (51549-35-0) → [9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(3-nitro-[1,2,4]triazol-1-yl)-9H-purin-2-yl]-[(4-methoxy-phenyl)-diphenyl-methyl]-amine (93170-46-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / DMAP / pyridine

2: 11 percent / o-chlorophenylphosphorodichloridate / pyridine

With dmap; 2-chlorophenyl dichlorophosphate; In pyridine;

DOI:10.1016/S0040-4039(01)91006-8

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → [9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(3-nitro-[1,2,4]triazol-1-yl)-9H-purin-2-yl]-[(4-methoxy-phenyl)-diphenyl-methyl]-amine (93170-46-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / imidazole / dimethylformamide

2: 96 percent / DMAP / pyridine

3: 11 percent / o-chlorophenylphosphorodichloridate / pyridine

With 1H-imidazole; dmap; 2-chlorophenyl dichlorophosphate; In pyridine; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(01)91006-8

upstream raw materials:

9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-9H-purin-6-ol

3-nitro-1,2,4-triazole

3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

tert-butyldimethylsilyl chloride

Downstream raw materials:

C₆₅H₁₀₀N₈O₉Si₄

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