N-((S)-1-(5-amino-3-bromo-6-cyanopyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamide

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Chemical Name:N-((S)-1-(5-amino-3-bromo-6-cyanopyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamide
CAS No.:1620056-56-5
Molecular Formula:C₂₄H₁₆BrF₇N₆O
Molecular Weight:617.323
Hs Code.:

N-((S)-1-(5-amino-3-bromo-6-cyanopyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamide

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Chemical Property of N-((S)-1-(5-amino-3-bromo-6-cyanopyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamide

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Technology Process of N-((S)-1-(5-amino-3-bromo-6-cyanopyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamide

There total 12 articles about N-((S)-1-(5-amino-3-bromo-6-cyanopyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620056-55-4
N-(2,5-dibromo-6-((S)-1-(2-((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamido)-2-(3,5-difluorophenyl)ethyl)pyridin-3-yl)-2,2,2-trifluoroacetamide

: cuprous cyanide

: 1620056-56-5
N-((S)-1-(5-amino-3-bromo-6-cyanopyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamide

Guidance literature:: at 100 ℃;

Reference yield:

: 186593-43-1
5-amino-3-bromo-2-methylpyridine

: 1620056-56-5
N-((S)-1-(5-amino-3-bromo-6-cyanopyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamide

Guidance literature:: Multi-step reaction with 12 steps

1: sodium acetate; acetic acid / Reflux

2: selenium(IV) oxide / 1,2-dimethoxyethane / 20 h / 130 °C

3: copper(II) sulfate / dichloromethane / 2 h / 20 °C

4: copper(II) bis(trifluoromethanesulfonate) / tetrahydrofuran; dichloromethane / 1 h / 0 - 20 °C

5: hydrogenchloride / methanol; 1,4-dioxane / 0.17 h / 0 - 20 °C

6: triethylamine / dichloromethane / 0 °C

7: hydrazine hydrate / ethanol / 2 h / 20 °C

8: N-Bromosuccinimide / acetonitrile / 0.08 h / 0 °C

9: potassium carbonate / 1,4-dioxane / 0.08 h / 0 °C

10: dichloromethane / 1 h / 0 - 20 °C

11: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h / 0 °C

12: 100 °C

With hydrogenchloride; selenium(IV) oxide; N-Bromosuccinimide; sodium acetate; copper(II) bis(trifluoromethanesulfonate); potassium carbonate; hydrazine hydrate; copper(II) sulfate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1620056-30-5
2-(5-bromo-6-methylpyridin-3-yl)isoindoline-1,3-dione

: 1620056-56-5
N-((S)-1-(5-amino-3-bromo-6-cyanopyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamide

Guidance literature:: Multi-step reaction with 11 steps

1: selenium(IV) oxide / 1,2-dimethoxyethane / 20 h / 130 °C

2: copper(II) sulfate / dichloromethane / 2 h / 20 °C

3: copper(II) bis(trifluoromethanesulfonate) / tetrahydrofuran; dichloromethane / 1 h / 0 - 20 °C

4: hydrogenchloride / methanol; 1,4-dioxane / 0.17 h / 0 - 20 °C

5: triethylamine / dichloromethane / 0 °C

6: hydrazine hydrate / ethanol / 2 h / 20 °C

7: N-Bromosuccinimide / acetonitrile / 0.08 h / 0 °C

8: potassium carbonate / 1,4-dioxane / 0.08 h / 0 °C

9: dichloromethane / 1 h / 0 - 20 °C

10: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h / 0 °C

11: 100 °C

With hydrogenchloride; selenium(IV) oxide; N-Bromosuccinimide; copper(II) bis(trifluoromethanesulfonate); potassium carbonate; hydrazine hydrate; copper(II) sulfate; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;