Carbamic acid, [1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]octahydro-5-oxo-6-indolizinyl]-, 1,1-dimethylethyl ester, [1S-(1alpha,6alpha,8abeta)]-

Base Information

Chemical Name:Carbamic acid, [1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]octahydro-5-oxo-6-indolizinyl]-, 1,1-dimethylethyl ester, [1S-(1alpha,6alpha,8abeta)]-
CAS No.:146987-11-3
Molecular Formula:C₁₉H₃₆N₂O₄Si
Molecular Weight:384.591
Hs Code.:
DSSTox Substance ID:DTXSID401102223
Nikkaji Number:J531.566B

Carbamic acid, [1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]octahydro-5-oxo-6-indolizinyl]-, 1,1-dimethylethyl ester, [1S-(1alpha,6alpha,8abeta)]-

Synonyms:DTXSID401102223;146987-11-3;Carbamic acid, [1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]octahydro-5-oxo-6-indolizinyl]-, 1,1-dimethylethyl ester, [1S-(1alpha,6alpha,8abeta)]-;N-[[(1S)-1beta-(tert-Butyldimethylsilyloxy)-1,2,3,5,6,7,8,8aalpha-octahydro-5-oxoindolizin]-6beta-yl]carbamic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, [1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]octahydro-5-oxo-6-indolizinyl]-, 1,1-dimethylethyl ester, [1S-(1alpha,6alpha,8abeta)]-

Chemical Property:

Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:384.24443417
Heavy Atom Count:26
Complexity:551

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1CCC2C(CCN2C1=O)O[Si](C)(C)C(C)(C)C
Isomeric SMILES:CC(C)(C)OC(=O)N[C@H]1CC[C@H]2[C@H](CCN2C1=O)O[Si](C)(C)C(C)(C)C

Technology Process of Carbamic acid, [1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]octahydro-5-oxo-6-indolizinyl]-, 1,1-dimethylethyl ester, [1S-(1alpha,6alpha,8abeta)]-

There total 7 articles about Carbamic acid, [1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]octahydro-5-oxo-6-indolizinyl]-, 1,1-dimethylethyl ester, [1S-(1alpha,6alpha,8abeta)]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 146987-13-5
(1S,6S,SR)-6-<(tert-butoxycarbonyl)amino>-1-<(tert-butyldimethylsilyl)oxy>-1,2,3,5,6,7-hexahydro-8-<(4-methylphenyl)sulfinyl>-5-indolizinone

: 146987-11-3
(1S,6S,8aS)-6-<(tert-butoxycarbonyl)amino>-1-<(tert-butyldimethylsilyl)oxy>-1,2,3,5,6,7,8,8a-octahydro-5-indolizinone

Guidance literature:: With hydrogen; nickel; In ethanol; at 50 ℃; under 2585.7 Torr;
DOI:10.1021/jo00060a034

Reference yield: 76.0%

: 146955-16-0
(1S,6S,SS)-6-<(tert-butoxycarbonyl)amino>-1-<(tert-butyldimethylsilyl)oxy>-1,2,3,5,6,7-hexahydro-8-<(4-methylphenyl)sulfinyl>-5-indolizinone

: 146987-11-3
(1S,6S,8aS)-6-<(tert-butoxycarbonyl)amino>-1-<(tert-butyldimethylsilyl)oxy>-1,2,3,5,6,7,8,8a-octahydro-5-indolizinone

Guidance literature:: With hydrogen; nickel; In ethanol; at 50 ℃; for 2h; under 2585.7 Torr;
DOI:10.1021/jo00060a034

Reference yield:

: 126645-93-0
4-<(tert-butyldimethylsilyl)oxy>-3,4-dihydro-5-methyl-2H-pyrrole

: 146987-11-3
(1S,6S,8aS)-6-<(tert-butoxycarbonyl)amino>-1-<(tert-butyldimethylsilyl)oxy>-1,2,3,5,6,7,8,8a-octahydro-5-indolizinone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, -25 deg C, 30 min, 2.) THF, -25 deg C, 1.5 h

With lithium diisopropyl amide;
DOI:10.1021/jo00060a034