Technology Process of 2-amino-1-(isopropylsulfonyl)-1H-imidazo<4,5-d>pyridin-6-yl phenyl ketone
There total 6 articles about 2-amino-1-(isopropylsulfonyl)-1H-imidazo<4,5-d>pyridin-6-yl phenyl ketone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) PCl5 2.) AlCl3 / 1.a) 7 h, reflux b) 18 h, r.t. 2.) 1.5 h, reflux
2: 83 percent / aq. NH4OH / methanol / 2.5 h / Heating
3: H2 / platinum oxide / aq. ethanol / 0.67 h / 1034.3 - 2585.7 Torr
4: 1.) triethylamine 2.) dicyclohexylcarbodiimide / 1.) acetonitrile, 10 min 2.) 2 h, reflux
5: 38 percent / 4M aq. NaOH / 2 h / steam bath
6: 31 percent / K2CO3 / dimethylformamide / 2.5 h
With
ammonium hydroxide; sodium hydroxide; aluminium trichloride; phosphorus pentachloride; hydrogen; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide;
platinum(IV) oxide;
In
methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570270656
- Guidance literature:
-
Multi-step reaction with 4 steps
1: H2 / platinum oxide / aq. ethanol / 0.67 h / 1034.3 - 2585.7 Torr
2: 1.) triethylamine 2.) dicyclohexylcarbodiimide / 1.) acetonitrile, 10 min 2.) 2 h, reflux
3: 38 percent / 4M aq. NaOH / 2 h / steam bath
4: 31 percent / K2CO3 / dimethylformamide / 2.5 h
With
sodium hydroxide; hydrogen; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide;
platinum(IV) oxide;
In
ethanol; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570270656
