Technology Process of 4-amino-3-(2-benzyloxyethoxy)methyl-5-cyanopyrazole
There total 8 articles about 4-amino-3-(2-benzyloxyethoxy)methyl-5-cyanopyrazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic anhydride;
In
1,4-dioxane; pyridine;
for 1.5h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 73 percent / conc. H2SO4 / 3 h / Heating
2: 72 percent / fuming HNO3, Ac2O / acetic acid / 1 h / Ambient temperature
3: 63 percent / triethylamine / CH2Cl2 / 0.17 h / 6 °C
4: DMF, thionylchloride / 4 h / Heating
5: 2,6-dimethylpyridine, silver tetrafluoroborate / acetonitrile / 50 °C
6: 27 g / conc. NH3 / dioxane / 8 h / 110 °C
7: 61 percent / KHCO3, sodium dithionite / ethanol; ethyl acetate; H2O / 1 h
8: 67 percent / trifluoroacetic anhydride / pyridine; dioxane / 1.5 h
With
2,6-dimethylpyridine; ammonium hydroxide; silver tetrafluoroborate; thionyl chloride; sodium dithionite; sulfuric acid; nitric acid; acetic anhydride; potassium hydrogencarbonate; triethylamine; N,N-dimethyl-formamide; trifluoroacetic anhydride;
In
1,4-dioxane; pyridine; ethanol; dichloromethane; water; acetic acid; ethyl acetate; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 2,6-dimethylpyridine, silver tetrafluoroborate / acetonitrile / 50 °C
2: 27 g / conc. NH3 / dioxane / 8 h / 110 °C
3: 61 percent / KHCO3, sodium dithionite / ethanol; ethyl acetate; H2O / 1 h
4: 67 percent / trifluoroacetic anhydride / pyridine; dioxane / 1.5 h
With
2,6-dimethylpyridine; ammonium hydroxide; silver tetrafluoroborate; sodium dithionite; potassium hydrogencarbonate; trifluoroacetic anhydride;
In
1,4-dioxane; pyridine; ethanol; water; ethyl acetate; acetonitrile;
