(S)-7-(Acetyl-benzyloxy-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-heptanoic acid 2-trimethylsilanyl-ethyl ester

Base Information

Chemical Name:(S)-7-(Acetyl-benzyloxy-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-heptanoic acid 2-trimethylsilanyl-ethyl ester
CAS No.:727426-50-8
Molecular Formula:C₄₈H₇₅N₅O₁₀Si
Molecular Weight:910.237
Hs Code.:

(S)-7-(Acetyl-benzyloxy-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-heptanoic acid 2-trimethylsilanyl-ethyl ester

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Chemical Property of (S)-7-(Acetyl-benzyloxy-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-heptanoic acid 2-trimethylsilanyl-ethyl ester

Chemical Property:

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Technology Process of (S)-7-(Acetyl-benzyloxy-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-heptanoic acid 2-trimethylsilanyl-ethyl ester

There total 12 articles about (S)-7-(Acetyl-benzyloxy-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-heptanoic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 622-33-3
N-benzyloxyamine

: 727426-50-8
(S)-7-(Acetyl-benzyloxy-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-heptanoic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: DIEA / methanol

2: trifluoroacetic acid

3: acylase

4: Et₃N

5: DCC; DMAP

6: trifluoroacetic acid

7: HBTU; HOBt*H₂O; Et₃N

With dmap; acylase; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In methanol;
DOI:10.1016/j.bmcl.2004.03.018

Reference yield:

: 4797-81-3
N-benzyloxyacetamide

: 727426-50-8
(S)-7-(Acetyl-benzyloxy-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-heptanoic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: KI; K₂CO₃ / acetone / 36 h / Heating

2: trifluoroacetic acid

3: HBTU; HOBt*H₂O; Et₃N

With potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; trifluoroacetic acid; potassium iodide; In acetone;
DOI:10.1016/j.bmcl.2004.03.018

Reference yield:

: 669091-26-3
N-acetyl-DL-7-bromoheptanoic acid

: 727426-50-8
(S)-7-(Acetyl-benzyloxy-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-heptanoic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: DMAP

2: DIEA / methanol

3: trifluoroacetic acid

4: acylase

5: Et₃N

6: DCC; DMAP

7: trifluoroacetic acid

8: HBTU; HOBt*H₂O; Et₃N

With dmap; acylase; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In methanol;
DOI:10.1016/j.bmcl.2004.03.018