2-Propanol, 1-[4-(5-chloro-1H-imidazol-2-YL)phen

Base Information

Chemical Name:2-Propanol, 1-[4-(5-chloro-1H-imidazol-2-YL)phen
CAS No.:102152-27-2
Molecular Formula:C₂₂H₂₆ClN₃O₄
Molecular Weight:431.919
Hs Code.:
ChEMBL ID:CHEMBL416150
DSSTox Substance ID:DTXSID80875379

Synonyms:CHEMBL416150;DTXSID80875379;2-PROPANOL, 1-[4-(5-CHLORO-1H-IMIDAZOL-2-YL)PHEN;BDBM50405434;102152-27-2

Suppliers and Price of 2-Propanol, 1-[4-(5-chloro-1H-imidazol-2-YL)phen

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Propanol, 1-[4-(5-chloro-1H-imidazol-2-YL)phen

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:11
Exact Mass:431.1611840
Heavy Atom Count:30
Complexity:481

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)CCNCC(COC2=CC=C(C=C2)C3=NC=C(N3)Cl)O)OC

Technology Process of 2-Propanol, 1-[4-(5-chloro-1H-imidazol-2-YL)phen

There total 4 articles about 2-Propanol, 1-[4-(5-chloro-1H-imidazol-2-YL)phen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-5-[4-(5-Chloro-1H-imidazol-2-yl)-phenoxymethyl]-3-[2-(3,4-dimethoxy-phenyl)-ethyl]-oxazolidin-2-one

: 102152-27-2
(S)-4-hloro-2-<4-<3-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-2-hydroxypropoxy>phenyl>imidazole

Guidance literature:: With sodium hydroxide; In ethanol; for 2h; Yield given; Heating;
DOI:10.1021/jm00156a028

Reference yield:

: 102151-65-5
5-bromo-2-(p-methoxyphenyl)imidazole-4-carboxylic acid

: 102152-27-2
(S)-4-hloro-2-<4-<3-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-2-hydroxypropoxy>phenyl>imidazole

Guidance literature:: Multi-step reaction with 4 steps

1: HBr / acetic acid / 2.5 h / Heating

2: 49 percent / 12N HCl / 120 h / 120 °C

3: 1.) NaH / 1.) Me₂SO, 60 deg C, 15 min, 2.) Me₂SO, 60 deg C, overnight

4: 10percent NaOH / ethanol / 2 h / Heating

With hydrogenchloride; sodium hydroxide; hydrogen bromide; sodium hydride; In ethanol; acetic acid;
DOI:10.1021/jm00156a028

Reference yield:

: 81654-33-3
5-bromo-2-(p-methoxyphenyl)-4-(trifluoromethyl)imidazole

: 102152-27-2
(S)-4-hloro-2-<4-<3-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-2-hydroxypropoxy>phenyl>imidazole

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / 2.5N NaOH / 3 h / Heating

2: HBr / acetic acid / 2.5 h / Heating

3: 49 percent / 12N HCl / 120 h / 120 °C

4: 1.) NaH / 1.) Me₂SO, 60 deg C, 15 min, 2.) Me₂SO, 60 deg C, overnight

5: 10percent NaOH / ethanol / 2 h / Heating

With hydrogenchloride; sodium hydroxide; hydrogen bromide; sodium hydride; In ethanol; acetic acid;
DOI:10.1021/jm00156a028