Multi-step reaction with 4 steps
1.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 16 h / 18 - 25 °C / Inert atmosphere
2.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / acetonitrile; tetrahydrofuran / 20 h / 18 - 25 °C / Inert atmosphere
3.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate / acetonitrile; water / 3 h / 80 °C / Inert atmosphere
4.1: dichloromethane / 2 h / 18 - 25 °C / Inert atmosphere
4.2: 1 h / Inert atmosphere
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; hydrogenchloride; palladium diacetate; potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;
3.1: |Suzuki Coupling;
DOI:10.1021/jm5001216