methyl (S)-2-(4-chloro-2-methylquinolin-3-yl)-2-hydroxyacetate

Base Information

Chemical Name:methyl (S)-2-(4-chloro-2-methylquinolin-3-yl)-2-hydroxyacetate
CAS No.:1402597-30-1
Molecular Formula:C₁₃H₁₂ClNO₃
Molecular Weight:265.696
Hs Code.:

Synonyms:

Suppliers and Price of methyl (S)-2-(4-chloro-2-methylquinolin-3-yl)-2-hydroxyacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
3-Quinolineaceticacid,4-chloro-α-hydroxy-2-methyl-,methylester,(αS)-
500mg
$ 1800.00

Total 2 raw suppliers

Chemical Property of methyl (S)-2-(4-chloro-2-methylquinolin-3-yl)-2-hydroxyacetate

Chemical Property:

Boiling Point:409.4±40.0 °C(Predicted)
Density:1.355±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

3-Quinolineaceticacid,4-chloro-α-hydroxy-2-methyl-,methylester,(αS)- ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (S)-2-(4-chloro-2-methylquinolin-3-yl)-2-hydroxyacetate

There total 7 articles about methyl (S)-2-(4-chloro-2-methylquinolin-3-yl)-2-hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1402597-29-8
methyl 2-(4-chloro-2-methylquinolin-3-yl)-2-oxoacetate

: 1402597-30-1
methyl (S)-2-(4-chloro-2-methylquinolin-3-yl)-2-hydroxyacetate

Guidance literature:: methyl 2-(4-chloro-2-methylquinolin-3-yl)-2-oxoacetate; With formic acid; triethylamine; In acetonitrile; at -10 ℃; Inert atmosphere;

With dichloro(pentamethylcyclopentadienyl)rhodium(II) dimer; N-((1S,2S)-2-amino-1,2-diphenylethyl)-4-nitrobenzenesulfonamide; In acetonitrile; at -10 ℃; Reagent/catalyst; Inert atmosphere;
DOI:10.1002/anie.201501575

Reference yield:

: 607-67-0
4-hydroxy-2-methylquinoline

: 1402597-30-1
methyl (S)-2-(4-chloro-2-methylquinolin-3-yl)-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium iodide; sodium hydroxide; iodine / acetonitrile; water / 10 °C

2.1: triethylamine; trichlorophosphate / ethyl acetate / 22 °C / Reflux

3.1: isopropylmagnesium chloride; copper(I) bromide dimethylsulfide complex / tetrahydrofuran / -15 - -10 °C

3.2: 0.5 h / -15 - -10 °C

3.3: 0.33 h / 20 - 25 °C

4.1: triethylamine; formic acid / acetonitrile / -5 - 20 °C / Inert atmosphere

With formic acid; copper(I) bromide dimethylsulfide complex; iodine; isopropylmagnesium chloride; triethylamine; sodium iodide; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; water; ethyl acetate; acetonitrile;

Reference yield:

: 64965-49-7
4-hydroxy-3-iodo-2-methylquinoline

: 1402597-30-1
methyl (S)-2-(4-chloro-2-methylquinolin-3-yl)-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; trichlorophosphate / ethyl acetate / 22 °C / Reflux

2.1: isopropylmagnesium chloride; copper(I) bromide dimethylsulfide complex / tetrahydrofuran / -15 - -10 °C

2.2: 0.5 h / -15 - -10 °C

2.3: 0.33 h / 20 - 25 °C

3.1: triethylamine; formic acid / acetonitrile / -5 - 20 °C / Inert atmosphere

With formic acid; copper(I) bromide dimethylsulfide complex; isopropylmagnesium chloride; triethylamine; trichlorophosphate; In tetrahydrofuran; ethyl acetate; acetonitrile;