Technology Process of dibenzyl (3-(N-(benzyloxy)acetamido)-1-(1H-1,2,3-triazol-1-yl)propyl)phosphonate
There total 6 articles about dibenzyl (3-(N-(benzyloxy)acetamido)-1-(1H-1,2,3-triazol-1-yl)propyl)phosphonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
at 120 ℃;
for 6.5h;
Microwave irradiation;
DOI:10.1021/jm301577q
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium iodide / methanol; acetonitrile / 1 h / 20 °C
1.2: 1.08 h / 0 - 20 °C
2.1: potassium osmate(VI) dihydrate; sodium periodate / tetrahydrofuran; water / 4 h / Darkness
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C
3.2: 0.25 h / -78 °C
4.1: triphenylphosphine; di-isopropyl azodicarboxylate; sodium azide; sulfuric acid / water; toluene / 2 h / 0 - 20 °C
5.1: 6.5 h / 120 °C / Microwave irradiation
With
potassium osmate(VI) dihydrate; sodium periodate; sodium azide; di-isopropyl azodicarboxylate; sulfuric acid; triphenylphosphine; sodium iodide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; water; toluene; acetonitrile;
4.1: |Mitsunobu Displacement;
DOI:10.1021/jm301577q
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C
1.2: 1.5 h
2.1: sodium iodide / methanol; acetonitrile / 1 h / 20 °C
2.2: 1.08 h / 0 - 20 °C
3.1: potassium osmate(VI) dihydrate; sodium periodate / tetrahydrofuran; water / 4 h / Darkness
4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C
4.2: 0.25 h / -78 °C
5.1: triphenylphosphine; di-isopropyl azodicarboxylate; sodium azide; sulfuric acid / water; toluene / 2 h / 0 - 20 °C
6.1: 6.5 h / 120 °C / Microwave irradiation
With
potassium osmate(VI) dihydrate; sodium periodate; sodium azide; di-isopropyl azodicarboxylate; sulfuric acid; sodium hydride; triphenylphosphine; sodium iodide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;
5.1: |Mitsunobu Displacement;
DOI:10.1021/jm301577q
