Technology Process of N-(benzyloxy)-N-(but-3-enyl)acetamide
There total 2 articles about N-(benzyloxy)-N-(but-3-enyl)acetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl N-(benzyloxy)-N-(but-3-enyl)carbamate; acetyl chloride;
With
sodium iodide;
In
methanol; acetonitrile;
at 20 ℃;
for 1h;
With
dmap; triethylamine;
In
methanol; acetonitrile;
at 0 - 20 ℃;
for 1.08333h;
DOI:10.1021/jm301577q
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C
1.2: 1.5 h
2.1: sodium iodide / methanol; acetonitrile / 1 h / 20 °C
2.2: 1.08 h / 0 - 20 °C
With
sodium hydride; sodium iodide;
In
methanol; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1021/jm301577q
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium osmate(VI) dihydrate; sodium periodate / tetrahydrofuran; water / 4 h / Darkness
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C
2.2: 0.25 h / -78 °C
3.1: triphenylphosphine; di-isopropyl azodicarboxylate; sodium azide; sulfuric acid / water; toluene / 2 h / 0 - 20 °C
4.1: 6.5 h / 120 °C / Microwave irradiation
With
potassium osmate(VI) dihydrate; sodium periodate; sodium azide; di-isopropyl azodicarboxylate; sulfuric acid; triphenylphosphine; lithium hexamethyldisilazane;
In
tetrahydrofuran; water; toluene;
3.1: |Mitsunobu Displacement;
DOI:10.1021/jm301577q
