1-[(4R)-4-ethyl-Δ(2)-1,3-oxazolin-2-yl]-2-[(4S)-4-ethyl-Δ(2)-1,3-oxazolin-2-yl]benzene

Base Information

• Chemical Name: 1-[(4R)-4-ethyl-Δ(2)-1,3-oxazolin-2-yl]-2-[(4S)-4-ethyl-Δ(2)-1,3-oxazolin-2-yl]benzene
• CAS No.: 220336-40-3
• Molecular Formula: C₁₆H₂₀N₂O₂
• Molecular Weight: 272.347
• Mol file: 220336-40-3.mol

Synonyms:

Chemical Property of 1-[(4R)-4-ethyl-Δ(2)-1,3-oxazolin-2-yl]-2-[(4S)-4-ethyl-Δ(2)-1,3-oxazolin-2-yl]benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(4R)-4-ethyl-Δ(2)-1,3-oxazolin-2-yl]-2-[(4S)-4-ethyl-Δ(2)-1,3-oxazolin-2-yl]benzene

There total 1 articles about 1-[(4R)-4-ethyl-Δ(2)-1,3-oxazolin-2-yl]-2-[(4S)-4-ethyl-Δ(2)-1,3-oxazolin-2-yl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R)-2-aminobutan-1-ol (5856-63-3) + phthalonitrile (91-15-6) → 1,2-bis<(4R)-4-ethyl-3,4-dihydrooxazol-2-yl>benzene (220336-22-1) + 1-[(4R)-4-ethyl-Δ(2)-1,3-oxazolin-2-yl]-2-[(4S)-4-ethyl-Δ(2)-1,3-oxazolin-2-yl]benzene (220336-40-3)

Guidance literature:

With zinc(II) chloride; In toluene; for 24h; Yield given; Yields of byproduct given; Heating;

DOI:10.1039/a807946c

Reference yield: 89.0%

ammonium hexafluorophosphate + di-μ-chlorido-bis(η3-1,3-diphenylallyl)dipalladium(II) + 1-[(4R)-4-ethyl-Δ(2)-1,3-oxazolin-2-yl]-2-[(4S)-4-ethyl-Δ(2)-1,3-oxazolin-2-yl]benzene (220336-40-3) → (η(3)-1,3-diphenylallyl)[1-[(4R)-(4-ethyl-Δ(2)-1,3-oxazolin-2-yl)-2-(4S)-(4-ethyl-Δ(2)-1,3-oxazolin-2-yl)]benzene-N,N]palladium(II) hexafluorophosphate

Guidance literature:

In ethanol; dichloromethane; Pd complex and ligand (molar ratio 1:2) dissolved in a mixt. of equal amts. of abs. EtOH, CH2Cl2, CHCl3 and MeOH under N2; stirred at room temp.for 30 min; NH4PF6 added; stirred at room temp. for 3 d; evapd., dissolved in CH2Cl2, extd. with H2O until neutral pH; org. phasedried over Na2SO4, evapd., Et2O added; resulting white solid dried in v acuo; elem. anal.; single crystal X-ray diffraction;

upstream raw materials:

(2R)-2-aminobutan-1-ol

phthalonitrile