(1'R,2R)-2-[(1',2'-O-Isopropylidene)dihydroxyethyl]-6-fluorochroman-4-one

Base Information

Chemical Name:(1'R,2R)-2-[(1',2'-O-Isopropylidene)dihydroxyethyl]-6-fluorochroman-4-one
CAS No.:797054-18-3
Molecular Formula:C₁₄H₁₅FO₄
Molecular Weight:266.269
Hs Code.:
DSSTox Substance ID:DTXSID10440079
Nikkaji Number:J2.462.361K
Wikidata:Q82256266
Mol file:797054-18-3.mol

Synonyms:797054-18-3;(1'R,2R)-2-[(1',2'-O-Isopropylidene)dihydroxyethyl]-6-fluorochroman-4-one;(2R)-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-6-fluoro-2,3-dihydrochromen-4-one;SCHEMBL6919626;DTXSID10440079;MYQKUOXZBKPFPP-CHWSQXEVSA-N;(R)-2-(2,2-Dimethyl-1,3-dioxolane-4beta-yl)-6-fluoro-2H-1-benzopyran-4(3H)-one;(1 inverted exclamation mark R,2R)-2-[(1 inverted exclamation mark ,2 inverted exclamation mark -O-Isopropylidene)dihydroxyethyl]-6-fluorochroman-4-one

Suppliers and Price of (1'R,2R)-2-[(1',2'-O-Isopropylidene)dihydroxyethyl]-6-fluorochroman-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(1’R,2R)-2-[(1’,2’-O-Isopropylidene)dihydroxyethyl]-6-fluorochroman-4-one
250mg
$ 140.00

Total 3 raw suppliers

Chemical Property of (1'R,2R)-2-[(1',2'-O-Isopropylidene)dihydroxyethyl]-6-fluorochroman-4-one

Chemical Property:

Melting Point:65-67°C
Storage Temp.:Refrigerator
Solubility.:Chloroform, Dichloromethane, MethanolChloroform, Methanol
XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:266.09543712
Heavy Atom Count:19
Complexity:371

Purity/Quality:

99% ^*data from raw suppliers

(1’R,2R)-2-[(1’,2’-O-Isopropylidene)dihydroxyethyl]-6-fluorochroman-4-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(OCC(O1)C2CC(=O)C3=C(O2)C=CC(=C3)F)C
Isomeric SMILES:CC1(OC[C@@H](O1)[C@H]2CC(=O)C3=C(O2)C=CC(=C3)F)C

Technology Process of (1'R,2R)-2-[(1',2'-O-Isopropylidene)dihydroxyethyl]-6-fluorochroman-4-one

There total 5 articles about (1'R,2R)-2-[(1',2'-O-Isopropylidene)dihydroxyethyl]-6-fluorochroman-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 797054-16-1
(E)-(4R)-4,5-isopropylydene-dioxy-1-(2-hydroxy-5-fluoro-phenyl)-prop-2E-ene-1-one

: 797054-19-4
(S)-2-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-6-fluoro-2,3-dihydrochromen-4-one

: 797054-18-3
(R)-2-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-6-fluoro-2,3-dihydrochromen-4-one

Guidance literature:: With lithium hydroxide; In water; at 60 ℃; for 1h;

Reference yield: 24.0%

: 394-32-1
1-(5-fluoro-2-hydroxyphenyl)ethan-1-one

: 15186-48-8
2,3-isopropylidene-glyceraldehyde

: 797054-19-4
(S)-2-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-6-fluoro-2,3-dihydrochromen-4-one

: 797054-18-3
(R)-2-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-6-fluoro-2,3-dihydrochromen-4-one

Guidance literature:: pyrrolidine; In toluene;
DOI:10.1055/s-2007-965993

Reference yield:

: 371-41-5
4-Fluorophenol

: 797054-18-3
(R)-2-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-6-fluoro-2,3-dihydrochromen-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / AlCl₃ / 2 h / 130 °C

2: 16 percent / pyrrolidine / toluene

With aluminium trichloride; pyrrolidine; In toluene;
DOI:10.1055/s-2007-965993