Technology Process of methyl [3-[[(2S)-[(2R)-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1H-indol-7-yloxy]acetate
There total 10 articles about methyl [3-[[(2S)-[(2R)-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1H-indol-7-yloxy]acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: phosphorus oxychloride / 2 h / 20 °C
2: ammonium acetate; Ac2O; AcONa / AcOH / 2 h / Heating
3: LiAlH4 / tetrahydrofuran; diethyl ether / 5.5 h / Heating
4: 47 percent / methanol / 28 h / 20 °C
5: 36 percent / Et3N / tetrahydrofuran / 16 h / 20 °C
6: H2 / Rh/C / ethanol / 50 - 55 °C / atmospheric pressure
7: K2CO3; KI / methanol; acetone / Heating
8: aq. NaOH / ethanol / Heating
9: SOCl2 / 0 - 20 °C
With
ammonium acetate; sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; hydrogen; sodium acetate; acetic anhydride; potassium carbonate; triethylamine; potassium iodide; trichlorophosphate;
Rh on carbon; acetic acid;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; acetone;
1: Vilsmeier reaction;
DOI:10.1248/cpb.53.184
- Guidance literature:
-
Multi-step reaction with 8 steps
1: ammonium acetate; Ac2O; AcONa / AcOH / 2 h / Heating
2: LiAlH4 / tetrahydrofuran; diethyl ether / 5.5 h / Heating
3: 47 percent / methanol / 28 h / 20 °C
4: 36 percent / Et3N / tetrahydrofuran / 16 h / 20 °C
5: H2 / Rh/C / ethanol / 50 - 55 °C / atmospheric pressure
6: K2CO3; KI / methanol; acetone / Heating
7: aq. NaOH / ethanol / Heating
8: SOCl2 / 0 - 20 °C
With
ammonium acetate; sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; hydrogen; sodium acetate; acetic anhydride; potassium carbonate; triethylamine; potassium iodide;
Rh on carbon; acetic acid;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; acetone;
DOI:10.1248/cpb.53.184
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 47 percent / methanol / 28 h / 20 °C
2: 36 percent / Et3N / tetrahydrofuran / 16 h / 20 °C
3: H2 / Rh/C / ethanol / 50 - 55 °C / atmospheric pressure
4: K2CO3; KI / methanol; acetone / Heating
5: aq. NaOH / ethanol / Heating
6: SOCl2 / 0 - 20 °C
With
sodium hydroxide; thionyl chloride; hydrogen; potassium carbonate; triethylamine; potassium iodide;
Rh on carbon;
In
tetrahydrofuran; methanol; ethanol; acetone;
DOI:10.1248/cpb.53.184
