2-Phenyl-3,1-benzoxazepine

Base Information

• Chemical Name: 2-Phenyl-3,1-benzoxazepine
• CAS No.: 14300-21-1
• Molecular Formula: C15H11 N O
• Molecular Weight: 221.258
• Hs Code.: 2934999090
• Mol file: 14300-21-1.mol

Synonyms:2-Phenyl-4,5-benz-1,3-oxazepin;3,1-Benzoxazepine,2-phenyl;

Chemical Property of 2-Phenyl-3,1-benzoxazepine

Chemical Property:

• Vapor Pressure: 4.68E-05mmHg at 25°C
• Boiling Point: 360.2°C at 760 mmHg
• Flash Point: 139.5°C
• PSA: 21.59000
• Density: 1.1g/cm³
• LogP: 3.20140

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Phenyl-3,1-benzoxazepine

There total 5 articles about 2-Phenyl-3,1-benzoxazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-phenylquinoline 1-oxide (5659-33-6) → 2-phenylbenzo[d][1,3]oxazepine (14300-21-1)

Guidance literature:

In toluene; for 0.166667h; UV-irradiation; Flow reactor;

DOI:10.1016/j.tet.2018.05.066

Reference yield: 6.0%

1-Azido-1-phenyl-1H-isochromene → 2-phenylbenzo[d][1,3]oxazepine (14300-21-1) + 2-(o-Benzoylphenyl)acetaldehyde (58668-70-5) + Isochromen-(1Z)-ylidene-phenyl-amine

Guidance literature:

In xylene; at 130 ℃;

Reference yield:

quinoline (91-22-5) → 2-phenylbenzo[d][1,3]oxazepine (14300-21-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium perborate tetrahydrate / acetic acid / 40 °C

2: tert.-butylnitrite / acetonitrile / 18 h / 20 - 40 °C

3: toluene / 0.17 h / UV-irradiation; Flow reactor

With tert.-butylnitrite; sodium perborate tetrahydrate; In acetic acid; toluene; acetonitrile;

DOI:10.1016/j.tet.2018.05.066

upstream raw materials:

2-phenylquinoline 1-oxide

quinoline

Quinoline N-oxide

Downstream raw materials:

2-phenyl-1H-indol-3-carboxaldehyde

Refernces

• 1、 Le Roux, Jean-Pierre,Desbene, Paul-Louis,Cherton, Jean-Claude. "1-Azidoisochromenes. A New Route to 3,1-benzoxazepines". . p. 847 - 849. Retrieved 2007/10/02.