3-[5-benzyl-2-(1H-indazol-5-ylmethyl)-3-oxo-1-(3-phenyl-propionyl)-6-(2-trimethylsilanyl-ethoxymethoxy)-[1,2,4]triazepan-4-ylmethyl]-N-hydroxy-benzamidine

Base Information

Chemical Name:3-[5-benzyl-2-(1H-indazol-5-ylmethyl)-3-oxo-1-(3-phenyl-propionyl)-6-(2-trimethylsilanyl-ethoxymethoxy)-[1,2,4]triazepan-4-ylmethyl]-N-hydroxy-benzamidine
CAS No.:871905-33-8
Molecular Formula:C₄₂H₅₁N₇O₅Si
Molecular Weight:761.996
Hs Code.:

3-[5-benzyl-2-(1<i>H</i>-indazol-5-ylmethyl)-3-oxo-1-(3-phenyl-propionyl)-6-(2-trimethylsilanyl-ethoxymethoxy)-[1,2,4]triazepan-4-ylmethyl]-<i>N</i>-hydroxy-benzamidine

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Chemical Property of 3-[5-benzyl-2-(1H-indazol-5-ylmethyl)-3-oxo-1-(3-phenyl-propionyl)-6-(2-trimethylsilanyl-ethoxymethoxy)-[1,2,4]triazepan-4-ylmethyl]-N-hydroxy-benzamidine

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Technology Process of 3-[5-benzyl-2-(1H-indazol-5-ylmethyl)-3-oxo-1-(3-phenyl-propionyl)-6-(2-trimethylsilanyl-ethoxymethoxy)-[1,2,4]triazepan-4-ylmethyl]-N-hydroxy-benzamidine

There total 8 articles about 3-[5-benzyl-2-(1H-indazol-5-ylmethyl)-3-oxo-1-(3-phenyl-propionyl)-6-(2-trimethylsilanyl-ethoxymethoxy)-[1,2,4]triazepan-4-ylmethyl]-N-hydroxy-benzamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871905-64-5
(5R,6R)-5-Benzyl-2-(1H-indazol-5-ylmethyl)-1-(3-phenyl-propionyl)-6-(2-trimethylsilanyl-ethoxymethoxy)-[1,2,4]triazepan-3-one

: 871905-33-8
3-[5-benzyl-2-(1H-indazol-5-ylmethyl)-3-oxo-1-(3-phenyl-propionyl)-6-(2-trimethylsilanyl-ethoxymethoxy)-[1,2,4]triazepan-4-ylmethyl]-N-hydroxy-benzamidine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmcl.2005.08.093

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 871905-33-8
3-[5-benzyl-2-(1H-indazol-5-ylmethyl)-3-oxo-1-(3-phenyl-propionyl)-6-(2-trimethylsilanyl-ethoxymethoxy)-[1,2,4]triazepan-4-ylmethyl]-N-hydroxy-benzamidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 65 percent / (i-Pr)2NEt / CH₂Cl₂ / 20 °C

2.1: 100 percent / H₂ / Pd/C / methanol / 4 h / 20 °C

3.1: 62 percent / CH₂Cl₂ / 144 h / 20 °C

4.1: 100 percent / H₂ / Pd(OH)2/C / methanol / 2 h / 20 °C

5.1: pyridine / CH₂Cl₂ / 20 °C

6.1: t-BuOK / tetrahydrofuran / 20 °C

6.2: tetrahydrofuran / 20 °C

7.1: NaH / dimethylformamide / 20 °C

With pyridine; potassium tert-butylate; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.08.093

Reference yield:

: 178059-32-0
(1R,2R)-1-Benzyl-3-(N-benzyl-hydrazino)-2-(2-trimethylsilanyl-ethoxymethoxy)-propylamine

: 871905-33-8
3-[5-benzyl-2-(1H-indazol-5-ylmethyl)-3-oxo-1-(3-phenyl-propionyl)-6-(2-trimethylsilanyl-ethoxymethoxy)-[1,2,4]triazepan-4-ylmethyl]-N-hydroxy-benzamidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 62 percent / CH₂Cl₂ / 144 h / 20 °C

2.1: 100 percent / H₂ / Pd(OH)2/C / methanol / 2 h / 20 °C

3.1: pyridine / CH₂Cl₂ / 20 °C

4.1: t-BuOK / tetrahydrofuran / 20 °C

4.2: tetrahydrofuran / 20 °C

5.1: NaH / dimethylformamide / 20 °C

With pyridine; potassium tert-butylate; hydrogen; sodium hydride; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.08.093