(1R,2R)-1-Benzyl-3-(N-benzyl-hydrazino)-2-(2-trimethylsilanyl-ethoxymethoxy)-propylamine

Base Information

Chemical Name:(1R,2R)-1-Benzyl-3-(N-benzyl-hydrazino)-2-(2-trimethylsilanyl-ethoxymethoxy)-propylamine
CAS No.:178059-32-0
Molecular Formula:C₂₃H₃₇N₃O₂Si
Molecular Weight:415.651
Hs Code.:

Synonyms:(1R,2R)-1-Benzyl-3-(N-benzyl-hydrazino)-2-(2-trimethylsilanyl-ethoxymethoxy)-propylamine

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Chemical Property of (1R,2R)-1-Benzyl-3-(N-benzyl-hydrazino)-2-(2-trimethylsilanyl-ethoxymethoxy)-propylamine

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Technology Process of (1R,2R)-1-Benzyl-3-(N-benzyl-hydrazino)-2-(2-trimethylsilanyl-ethoxymethoxy)-propylamine

There total 8 articles about (1R,2R)-1-Benzyl-3-(N-benzyl-hydrazino)-2-(2-trimethylsilanyl-ethoxymethoxy)-propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 178059-31-9
N'-Benzyl-N'-((2R,3R)-3-benzyloxycarbonylamino-2-hydroxy-4-phenyl-butyl)-hydrazinecarboxylic acid benzyl ester

: 178059-32-0
(1R,2R)-1-Benzyl-3-(N-benzyl-hydrazino)-2-(2-trimethylsilanyl-ethoxymethoxy)-propylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / (i-Pr)2NEt / CH₂Cl₂ / 20 °C

2: 100 percent / H₂ / Pd/C / methanol / 4 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2005.08.093

Reference yield:

: 63219-70-5
N-(benzyloxycarbonyl)-D-phenylalaninal

: 178059-32-0
(1R,2R)-1-Benzyl-3-(N-benzyl-hydrazino)-2-(2-trimethylsilanyl-ethoxymethoxy)-propylamine

Guidance literature:: Multi-step reaction with 7 steps

1: toluene / 1.) -78 deg C, 2 h 2.) RT, 0.5 h

2: 2.7 g / m-chloroperbenzoic acid / CH₂Cl₂ / Ambient temperature

3: 72 percent / propan-2-ol / 24 h / Heating

4: trifluoroacetic acid / CH₂Cl₂

6: 83 percent / diisopropylethylamine / dimethylformamide / 19 h / Ambient temperature

7: H₂ / 10percent Pd/C / methanol / 1 h

With hydrogen; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
DOI:10.1021/jm9507183

Reference yield:

: 95832-30-7
N-<(benzyloxy)carbonyl>-(2R)-amino-1-phenylbut-3-ene

: 178059-32-0
(1R,2R)-1-Benzyl-3-(N-benzyl-hydrazino)-2-(2-trimethylsilanyl-ethoxymethoxy)-propylamine

Guidance literature:: Multi-step reaction with 6 steps

1: 2.7 g / m-chloroperbenzoic acid / CH₂Cl₂ / Ambient temperature

2: 72 percent / propan-2-ol / 24 h / Heating

3: trifluoroacetic acid / CH₂Cl₂

5: 83 percent / diisopropylethylamine / dimethylformamide / 19 h / Ambient temperature

6: H₂ / 10percent Pd/C / methanol / 1 h

With hydrogen; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm9507183