1-methyl-3-({[3-methyl-2,6-dioxo-7-(2-oxo-2-phenylethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]methyl}-thio)-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carbonitrile

Base Information

• Chemical Name: 1-methyl-3-({[3-methyl-2,6-dioxo-7-(2-oxo-2-phenylethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]methyl}-thio)-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carbonitrile
• CAS No.: 1416209-40-9
• Molecular Formula: C₂₅H₂₂N₆O₃S
• Molecular Weight: 486.554
• Mol file: 1416209-40-9.mol

Synonyms:

Chemical Property of 1-methyl-3-({[3-methyl-2,6-dioxo-7-(2-oxo-2-phenylethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]methyl}-thio)-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methyl-3-({[3-methyl-2,6-dioxo-7-(2-oxo-2-phenylethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]methyl}-thio)-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carbonitrile

There total 4 articles about 1-methyl-3-({[3-methyl-2,6-dioxo-7-(2-oxo-2-phenylethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]methyl}-thio)-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-2-thioxo-2,5,6,7-tetrahydro-1H-cyclopenta[b]pyridine-3-carbonitrile (852399-78-1) + C15H13ClN4O3 (1170005-16-9) + 1-methyl-3-thioxo-3,5,6,7-tetrahydro-2H-cyclopenta[c]pyridine-4-carbonitrile (95546-95-5) → 1-methyl-3-({[3-methyl-2,6-dioxo-7-(2-oxo-2-phenylethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]methyl}-thio)-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carbonitrile (1416209-40-9) + 4-methyl-2-({[3-methyl-2,6-dioxo-7-(2-oxo-2-phenylethyl)-2,3,6,7-tetrahydro-1h-purin-8-yl]methyl}thio)-6,7-dihydro-5h-cyclopenta[b]pyridine-3-carbonitrile (1416209-41-0)

Guidance literature:

With potassium hydroxide; In water; N,N-dimethyl-formamide; at 15 ℃; Overall yield = 64 %; Overall yield = 0.47 g;

DOI:10.1007/s10593-012-1149-1

Reference yield:

8-(hydroxymethyl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione (27038-81-9) → 1-methyl-3-({[3-methyl-2,6-dioxo-7-(2-oxo-2-phenylethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]methyl}-thio)-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carbonitrile (1416209-40-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / water / Heating

1.2: 2 h / Reflux

2.1: thionyl chloride / 6 h / Reflux

3.1: potassium hydroxide / water; N,N-dimethyl-formamide / 15 °C

With thionyl chloride; potassium hydroxide; sodium hydroxide; In water; N,N-dimethyl-formamide;

DOI:10.1007/s10593-012-1149-1

Reference yield:

C15H14N4O4 (953079-61-3) → 1-methyl-3-({[3-methyl-2,6-dioxo-7-(2-oxo-2-phenylethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]methyl}-thio)-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carbonitrile (1416209-40-9)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 6 h / Reflux

2: potassium hydroxide / water; N,N-dimethyl-formamide / 15 °C

With thionyl chloride; potassium hydroxide; In water; N,N-dimethyl-formamide;

DOI:10.1007/s10593-012-1149-1

upstream raw materials:

4-methyl-2-thioxo-2,5,6,7-tetrahydro-1H-cyclopenta[b]pyridine-3-carbonitrile

C₁₅H₁₃ClN₄O₃

1-methyl-3-thioxo-3,5,6,7-tetrahydro-2H-cyclopenta[c]pyridine-4-carbonitrile

8-(hydroxymethyl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione

Downstream raw materials:

2,13-dimethyl-7-phenyl-4,5-dihydro-3H,8H-cyclopenta[4'',5'']pyrido[3'',2'':4',5']thieno[3',2':5,6]-[1,4]diazepino[7,1-f]purine-10,12(11H,13H)-dione

1,9-dimethyl-7-phenyl-11,12-dihydro-1H,6H-cyclopenta[5'',6'']pyrido[3'',2'':4',5']thieno[3',2':5,6][1,4]diazepino[7,1-f]purine-2,4(3H,10H)-dione