Technology Process of 1,1,8,8-tetrakis(3,5-di-tert-butylphenyl)-1,8-dimethoxyocta-2,4,6-triyne
There total 8 articles about 1,1,8,8-tetrakis(3,5-di-tert-butylphenyl)-1,8-dimethoxyocta-2,4,6-triyne which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
diazomethyl-trimethyl-silane;
With
n-butyllithium;
In
tetrahydrofuran; diethyl ether; hexane;
at -78 ℃;
for 0.5h;
Inert atmosphere;
1,1,7,7-tetrakis(3,5-di-tert-butylphenyl)-1,7-dimethoxyhepta-2,5-diyn-4-one;
In
tetrahydrofuran; diethyl ether; hexane;
at -78 ℃;
for 3h;
Inert atmosphere;
DOI:10.1002/anie.201208058
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: pyridinium chlorochromate / dichloromethane / 3 h / Molecular sieve
2.1: n-butyllithium / diethyl ether; hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.2: 3 h / -78 °C / Inert atmosphere
With
n-butyllithium; pyridinium chlorochromate;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane;
2.1: |Fritsch-Buttenberg-Wiechell Rearrangement / 2.2: |Fritsch-Buttenberg-Wiechell Rearrangement;
DOI:10.1002/anie.201208058
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: pyridinium chlorochromate / dichloromethane / 3 h / Molecular sieve
2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
2.2: 1 h / Inert atmosphere
3.1: hexane; tetrahydrofuran / 2 h / Inert atmosphere
4.1: potassium carbonate / methanol; tetrahydrofuran / 3 h
5.1: tetrahydrofuran / 0.33 h / Inert atmosphere
5.2: 0.5 h / Inert atmosphere
6.1: pyridinium chlorochromate / dichloromethane / 3 h / Molecular sieve
7.1: n-butyllithium / diethyl ether; hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
7.2: 3 h / -78 °C / Inert atmosphere
With
n-butyllithium; potassium carbonate; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane;
7.1: |Fritsch-Buttenberg-Wiechell Rearrangement / 7.2: |Fritsch-Buttenberg-Wiechell Rearrangement;
DOI:10.1002/anie.201208058
