methyl 3-[(2-amino-3-pyridyl)carbonyl]amino-4-(cyclopentylamino)benzoate

Base Information

• Chemical Name: methyl 3-[(2-amino-3-pyridyl)carbonyl]amino-4-(cyclopentylamino)benzoate
• CAS No.: 1430101-81-7
• Molecular Formula: C₁₉H₂₂N₄O₃
• Molecular Weight: 354.409
• Mol file: 1430101-81-7.mol

Synonyms:

Chemical Property of methyl 3-[(2-amino-3-pyridyl)carbonyl]amino-4-(cyclopentylamino)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-[(2-amino-3-pyridyl)carbonyl]amino-4-(cyclopentylamino)benzoate

There total 4 articles about methyl 3-[(2-amino-3-pyridyl)carbonyl]amino-4-(cyclopentylamino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-aminopyridin-3-carboxylic acid (5345-47-1) + methyl 3-amino 4-(cyclopentylamino)benzoate → methyl 3-[(2-amino-3-pyridyl)carbonyl]amino-4-(cyclopentylamino)benzoate (1430101-81-7)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 160 ℃; for 0.166667h; Microwave irradiation; Inert atmosphere;

DOI:10.1021/co400010y

Reference yield:

3-nitro-4-fluorobenzoic acid (453-71-4) → methyl 3-[(2-amino-3-pyridyl)carbonyl]amino-4-(cyclopentylamino)benzoate (1430101-81-7)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid / 0.25 h / 80 °C / Microwave irradiation; Inert atmosphere

2: dichloromethane / 0.17 h / 80 °C / Microwave irradiation; Inert atmosphere

3: zinc; ammonium formate / methanol / 0.08 h / 90 °C / Microwave irradiation; Inert atmosphere

4: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.17 h / 160 °C / Microwave irradiation; Inert atmosphere

With sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonium formate; triethylamine; zinc; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/co400010y

Reference yield:

4-fluoro-3-nitro-benzoic acid methyl ester (329-59-9) → methyl 3-[(2-amino-3-pyridyl)carbonyl]amino-4-(cyclopentylamino)benzoate (1430101-81-7)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 0.17 h / 80 °C / Microwave irradiation; Inert atmosphere

2: zinc; ammonium formate / methanol / 0.08 h / 90 °C / Microwave irradiation; Inert atmosphere

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.17 h / 160 °C / Microwave irradiation; Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonium formate; triethylamine; zinc; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/co400010y

upstream raw materials:

4-fluoro-3-nitro-benzoic acid methyl ester

3-nitro-4-fluorobenzoic acid

2-aminopyridin-3-carboxylic acid

methyl 4-(cyclopentylamino)-3-nitrobenzoate