methyl 4-(cyclopentylamino)-3-nitrobenzoate

Base Information

• Chemical Name: methyl 4-(cyclopentylamino)-3-nitrobenzoate
• CAS No.: 234750-98-2
• Molecular Formula: C₁₃H₁₆N₂O₄
• Molecular Weight: 264.281
• Mol file: 234750-98-2.mol

Synonyms:

Chemical Property of methyl 4-(cyclopentylamino)-3-nitrobenzoate

Chemical Property:

• Melting Point: 103-104 °C
• Boiling Point: 427.6±35.0 °C(Predicted)
• PKA: -1.21±0.20(Predicted)
• Density: 1.299±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Methyl4-(cyclopentylamino)-3-nitrobenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(cyclopentylamino)-3-nitrobenzoate

There total 5 articles about methyl 4-(cyclopentylamino)-3-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-nitro-4-chlorobenzoate (14719-83-6) + Cyclopentamine (1003-03-8) → methyl 4-(cyclopentylamino)-3-nitrobenzoate (234750-98-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide; for 18h; Reflux;

DOI:10.1016/j.ejmech.2015.01.018

Reference yield:

4-fluoro-3-nitro-benzoic acid methyl ester (329-59-9) + Cyclopentamine (1003-03-8) → methyl 4-(cyclopentylamino)-3-nitrobenzoate (234750-98-2)

Guidance literature:

In dichloromethane; at 80 ℃; for 0.166667h; Microwave irradiation; Inert atmosphere;

DOI:10.1021/co400010y

Reference yield:

3-nitro-4-fluorobenzoic acid (453-71-4) → methyl 4-(cyclopentylamino)-3-nitrobenzoate (234750-98-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 0.25 h / 80 °C / Microwave irradiation; Inert atmosphere

2: dichloromethane / 0.17 h / 80 °C / Microwave irradiation; Inert atmosphere

With sulfuric acid; In dichloromethane;

DOI:10.1021/co400010y

upstream raw materials:

methanol

3-nitro-4-fluorobenzoic acid

Cyclopentamine

4-fluoro-3-nitro-benzoic acid methyl ester

Downstream raw materials:

methyl 3-[(2-amino-3-pyridyl)carbonyl]amino-4-(cyclopentylamino)benzoate

methyl 2-(2-amino-5-phenylthiophen-3-yl)-1-cyclopentyl-1H-benzo[d]imidazole-5-carboxylate

methyl 1-cyclopentyl-2-(5-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-2-phenylthiophen-3-yl)-1H-benzo[d]imidazole-5-carboxylate