Technology Process of PF-05241328
There total 5 articles about PF-05241328 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine;
copper diacetate;
In
N,N-dimethyl-formamide;
at 50 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: toluene-4-sulfonic acid / tetrahydrofuran / 5 h / 80 °C
2.1: lithium hydroxide / tetrahydrofuran / 5 h / 80 °C
2.2: pH 3
3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14 h / 40 °C
4.1: hydrogenchloride / 1,4-dioxane / 6 h / 40 °C
5.1: pyridine / copper diacetate / N,N-dimethyl-formamide / 16 h / 50 °C
With
pyridine; hydrogenchloride; dmap; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide;
copper diacetate;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium hydroxide / tetrahydrofuran / 5 h / 80 °C
1.2: pH 3
2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14 h / 40 °C
3.1: hydrogenchloride / 1,4-dioxane / 6 h / 40 °C
4.1: pyridine / copper diacetate / N,N-dimethyl-formamide / 16 h / 50 °C
With
pyridine; hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide;
copper diacetate;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
