Methyl 3-Methyl-1H-indazole-5-carboxylate

Base Information

• Chemical Name: Methyl 3-Methyl-1H-indazole-5-carboxylate
• CAS No.: 1015068-76-4
• Molecular Formula: C10H10N2O2
• Molecular Weight: 190.19900
• Hs Code.: 2933990090
• Mol file: 1015068-76-4.mol

Synonyms:methyl 3-methyl-1H-indazole-5-carboxylate;3-methyl-1H-indazole-5-carboxylic acid methyl ester;

Chemical Property of Methyl 3-Methyl-1H-indazole-5-carboxylate

Chemical Property:

• PSA: 54.98000
• LogP: 1.65790
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl3-Methyl-1H-indazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 3-Methyl-1H-indazole-5-carboxylate is an intermediate used to prepare dual inhibitors of acetyl-CoA carboxylase 1 and 2.

Technology Process of Methyl 3-Methyl-1H-indazole-5-carboxylate

There total 7 articles about Methyl 3-Methyl-1H-indazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-bromo-3-methyl-1H-indazole (552331-16-5) + methanol (67-56-1) + carbon monoxide (201230-82-2) → 3-methyl-1H-indazole-5-carboxylic acid methyl ester (1015068-76-4)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; at 100 ℃; under 15201 Torr;

Reference yield: 64.0%

→ 3-methyl-1H-indazole-5-carboxylic acid methyl ester (1015068-76-4)

Guidance literature:

Reference yield:

methanol (67-56-1) + 1-(5-bromo-3-methyl-1H-indazol-1-yl)ethanone + carbon monoxide (201230-82-2) → 3-methyl-1H-indazole-5-carboxylic acid methyl ester (1015068-76-4)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; N-ethyl-N,N-diisopropylamine; palladium diacetate; In N,N-dimethyl-formamide; at 20 - 90 ℃; under 760.051 Torr;

upstream raw materials:

3-methyl-1H-indazole-5-carbonitrile

ethanol

tert-butyl 5-cyano-3-methyl-1H-indazolecarboxylate

sulfuric acid

Downstream raw materials:

Methyl 1-[(tert-butyl)oxycarbonyl]-3-methyl-1H-indazole-5-carboxylate

3-methyl-1H-indazole-5-carboxylic acid

PF-05241328

ethyl 3-(1-acetyl-3-methyl-1H-indazol-5-yl)-3-oxopropanoate

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