N-{(1S,2S)-1-benzyl-2-hydroxy-3-[1-(3-methoxyphenyl)-1-methylethylamino]propyl}-5-(1,1-dioxo-[1,2]thiazinan-2-yl)-N',N'-dipropylisophthalamide

Base Information

Chemical Name:N-{(1S,2S)-1-benzyl-2-hydroxy-3-[1-(3-methoxyphenyl)-1-methylethylamino]propyl}-5-(1,1-dioxo-[1,2]thiazinan-2-yl)-N',N'-dipropylisophthalamide
CAS No.:1539276-54-4
Molecular Formula:C₃₈H₅₂N₄O₆S
Molecular Weight:692.92
Hs Code.:

N-{(1S,2S)-1-benzyl-2-hydroxy-3-[1-(3-methoxyphenyl)-1-methylethylamino]propyl}-5-(1,1-dioxo-[1,2]thiazinan-2-yl)-N',N'-dipropylisophthalamide

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Chemical Property of N-{(1S,2S)-1-benzyl-2-hydroxy-3-[1-(3-methoxyphenyl)-1-methylethylamino]propyl}-5-(1,1-dioxo-[1,2]thiazinan-2-yl)-N',N'-dipropylisophthalamide

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Technology Process of N-{(1S,2S)-1-benzyl-2-hydroxy-3-[1-(3-methoxyphenyl)-1-methylethylamino]propyl}-5-(1,1-dioxo-[1,2]thiazinan-2-yl)-N',N'-dipropylisophthalamide

There total 11 articles about N-{(1S,2S)-1-benzyl-2-hydroxy-3-[1-(3-methoxyphenyl)-1-methylethylamino]propyl}-5-(1,1-dioxo-[1,2]thiazinan-2-yl)-N',N'-dipropylisophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1349180-49-9
5-(1,1-dioxo-[1,2]thiazinan-2-yl)-N,N-dipropylisophthalamic acid

: C₂₀H₂₈N₂O₂

: 1539276-54-4
N-{(1S,2S)-1-benzyl-2-hydroxy-3-[1-(3-methoxyphenyl)-1-methylethylamino]propyl}-5-(1,1-dioxo-[1,2]thiazinan-2-yl)-N',N'-dipropylisophthalamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 24h;
DOI:10.1021/ml4004952

Reference yield:

: 98760-08-8
(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane

: 1539276-54-4
N-{(1S,2S)-1-benzyl-2-hydroxy-3-[1-(3-methoxyphenyl)-1-methylethylamino]propyl}-5-(1,1-dioxo-[1,2]thiazinan-2-yl)-N',N'-dipropylisophthalamide

Guidance literature:: Multi-step reaction with 3 steps

1: isopropyl alcohol / 24 h / 70 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 24 h / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; isopropyl alcohol;
DOI:10.1021/ml4004952

Reference yield:

: 109138-28-5
1-(3-methoxyphenyl)-1-methylethylamine

: 1539276-54-4
N-{(1S,2S)-1-benzyl-2-hydroxy-3-[1-(3-methoxyphenyl)-1-methylethylamino]propyl}-5-(1,1-dioxo-[1,2]thiazinan-2-yl)-N',N'-dipropylisophthalamide

Guidance literature:: Multi-step reaction with 3 steps

1: isopropyl alcohol / 24 h / 70 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 24 h / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; isopropyl alcohol;
DOI:10.1021/ml4004952