Technology Process of 4-[2-(N-ethylaminoadamantan-2-yl)]-2'-hydroxybiphenyl hydrochloride
There total 6 articles about 4-[2-(N-ethylaminoadamantan-2-yl)]-2'-hydroxybiphenyl hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
ethanol; 4-(2-azidoadamantan-2-yl)-2'-hydroxybiphenyl;
at 70 ℃;
With
hydrogenchloride;
In
diethyl ether;
for 0.5h;
DOI:10.1139/V10-102
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / methanol; toluene / 24 h / Reflux; Inert atmosphere
2.1: iodine; magnesium / tetrahydrofuran / 20 °C / Inert atmosphere; Reflux
2.2: 20 °C / Reflux; Inert atmosphere
3.1: boron tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere
4.1: sodium azide; trifluoroacetic acid / chloroform / -5 - 20 °C
5.1: Raney Ni / 70 °C
5.2: 0.5 h
With
tetrakis(triphenylphosphine) palladium(0); sodium azide; iodine; boron tribromide; potassium carbonate; magnesium; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; toluene;
1.1: Suzuki reaction / 2.1: Grignard reaction;
DOI:10.1139/V10-102
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / methanol; toluene / 24 h / Reflux; Inert atmosphere
2.1: iodine; magnesium / tetrahydrofuran / 20 °C / Inert atmosphere; Reflux
2.2: 20 °C / Reflux; Inert atmosphere
3.1: boron tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere
4.1: sodium azide; trifluoroacetic acid / chloroform / -5 - 20 °C
5.1: Raney Ni / 70 °C
5.2: 0.5 h
With
tetrakis(triphenylphosphine) palladium(0); sodium azide; iodine; boron tribromide; potassium carbonate; magnesium; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; toluene;
1.1: Suzuki reaction / 2.1: Grignard reaction;
DOI:10.1139/V10-102
