2-bromo-2,3,4-trimethylanisole

Base Information

• Chemical Name: 2-bromo-2,3,4-trimethylanisole
• CAS No.: 103324-43-2
• Molecular Formula: C₁₀H₁₃BrO
• Molecular Weight: 229.117
• Mol file: 103324-43-2.mol

Synonyms:

Chemical Property of 2-bromo-2,3,4-trimethylanisole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-2,3,4-trimethylanisole

There total 1 articles about 2-bromo-2,3,4-trimethylanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-bromo-2,3,4-trimethylanisole (103324-43-2)

Guidance literature:

3,4,5-Trimethyl-anisol, CuBr2, sd. Me., 20h;

DOI:10.1021/jo01062a029

Reference yield: 72.0%

Triisopropyl borate (5419-55-6) + 2-bromo-2,3,4-trimethylanisole (103324-43-2) → 6-methoxy-2,3,4-trimethylphenylboronic acid (183377-76-6)

Guidance literature:

With butyllithium; In tetrahydrofuran; BuLi addn. to stirred org. compd. soln. at -78°C (N2), suspn. warming until solid dissolved, recooling to -78°C, stirring 1 h, B-compd. addn., stirring (-78°C/1.5 h, N2), warming to room temp., water addn., Et2O addn.; org. layer washing (satd. as. Na2SO4), drying (Na2SO4), filtration, solvent evapn. at 35°C, residue pulverization, air drying 2 d, stiring with pentane for 2 h, washings discarding; elem. anal.;

DOI:10.1039/p19960002173

Reference yield:

2-bromo-2,3,4-trimethylanisole (103324-43-2) → (6-methoxy-2,3,4-trimethylphenyl)phenyllead diacetate (183377-77-7)

Guidance literature:

Multi-step reaction with 2 steps

1: butyllithium / tetrahydrofuran

2: chloroform

With butyllithium; In tetrahydrofuran; chloroform;

DOI:10.1039/p19960002173

Downstream raw materials:

6-methoxy-2,3,4-trimethylphenylboronic acid

(6-methoxy-2,3,4-trimethylphenyl)phenyllead diacetate