(E)-3-(6-fluoro-1H-indol-3-yl)acrylonitrile

Base Information

• Chemical Name: (E)-3-(6-fluoro-1H-indol-3-yl)acrylonitrile
• CAS No.: 1316695-32-5
• Molecular Formula: C₁₁H₇FN₂
• Molecular Weight: 186.188
• Mol file: 1316695-32-5.mol

Synonyms:

Chemical Property of (E)-3-(6-fluoro-1H-indol-3-yl)acrylonitrile

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

(E)-3-(6-Fluoro-1H-indol-3-yl)acrylonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(6-fluoro-1H-indol-3-yl)acrylonitrile

There total 1 articles about (E)-3-(6-fluoro-1H-indol-3-yl)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

6-fluoro-1H-indole-3-carbaldehyde (2795-41-7) + cyanoacetic acid (372-09-8) → (Z)-3-(6-fluoro-1H-indol-3-yl)acrylonitrile (1350543-67-7) + (E)-3-(6-fluoro-1H-indol-3-yl)acrylonitrile (1316695-32-5)

Guidance literature:

cyanoacetic acid; With triethylamine; In methanol; at 20 ℃; for 0.166667h; Inert atmosphere;

6-fluoro-1H-indole-3-carbaldehyde; With piperidine; In methanol; at 150 ℃; for 10h; Inert atmosphere; Microwave irradiation;

DOI:10.1021/jm2006782

Reference yield: 64.0%

(E)-3-(6-fluoro-1H-indol-3-yl)acrylonitrile (1316695-32-5) → (E)-6-fluoro-3-[2-(1H-tetrazol-5-yl)vinyl]-1H-indole (1316695-35-8)

Guidance literature:

With aluminum (III) chloride; sodium azide; In tetrahydrofuran; for 18h; Inert atmosphere; Reflux;

DOI:10.1021/jm2006782

upstream raw materials:

6-fluoro-1H-indole-3-carbaldehyde

cyanoacetic acid

Downstream raw materials:

(E)-6-fluoro-3-[2-(1H-tetrazol-5-yl)vinyl]-1H-indole

Refernces