1H-Indole-5-carbonitrile, 1-(4-fluorophenyl)-3-[1,2,3,6-tetrahydro-1-[2-(2-oxo-1-imidazolidinyl)eth yl]-4-pyridinyl]-

Base Information

• Chemical Name: 1H-Indole-5-carbonitrile, 1-(4-fluorophenyl)-3-[1,2,3,6-tetrahydro-1-[2-(2-oxo-1-imidazolidinyl)eth yl]-4-pyridinyl]-
• CAS No.: 138900-26-2
• Molecular Formula: C25H24FN5O
• Molecular Weight: 429.497
• Mol file: 138900-26-2.mol

Synonyms:

Chemical Property of 1H-Indole-5-carbonitrile, 1-(4-fluorophenyl)-3-[1,2,3,6-tetrahydro-1-[2-(2-oxo-1-imidazolidinyl)eth yl]-4-pyridinyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indole-5-carbonitrile, 1-(4-fluorophenyl)-3-[1,2,3,6-tetrahydro-1-[2-(2-oxo-1-imidazolidinyl)eth yl]-4-pyridinyl]-

There total 1 articles about 1H-Indole-5-carbonitrile, 1-(4-fluorophenyl)-3-[1,2,3,6-tetrahydro-1-[2-(2-oxo-1-imidazolidinyl)eth yl]-4-pyridinyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-chloroethyl)imidazolidin-2-one (2387-20-4) + 1-(4-Fluoro-phenyl)-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole-5-carbonitrile → 1-(2-{4-[5-cyano-1-(4-fluorophenyl)-1H-indol-3-yl]-1,2,3,6-tetrahydropyridin-1-yl}ethyl)-2-imidazolidinone (138900-26-2)

Guidance literature:

With potassium carbonate; potassium iodide; In various solvent(s); for 16h; Heating;

DOI:10.1021/jm00084a014

Reference yield: 20.0%

1-(2-{4-[5-cyano-1-(4-fluorophenyl)-1H-indol-3-yl]-1,2,3,6-tetrahydropyridin-1-yl}ethyl)-2-imidazolidinone (138900-26-2) → 1-[2-[4-[5-aminomethyl-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinon (330944-26-8)

Guidance literature:

With hydrogen; platinum(IV) oxide; In acetic acid; at 20 ℃; for 5h; under 2206.52 Torr;

DOI:10.1016/S0968-0896(02)00459-5

Reference yield:

1-(2-{4-[5-cyano-1-(4-fluorophenyl)-1H-indol-3-yl]-1,2,3,6-tetrahydropyridin-1-yl}ethyl)-2-imidazolidinone (138900-26-2) → N-(1-(4-fluoro-phenyl)-3-{1-[2-(2-oxo-imidazolidin-1-yl)-ethyl]-piperidin-4-yl}-1H-indol-5-ylmethyl)-acetamide

Guidance literature:

Multi-step reaction with 2 steps

1: 20 percent / H₂ / PtO₂ / acetic acid / 5 h / 20 °C / 2206.52 Torr

2: 27 percent / NEt₃ / CH₂Cl₂ / 0 - 20 °C

With hydrogen; triethylamine; platinum(IV) oxide; In dichloromethane; acetic acid;

DOI:10.1016/S0968-0896(02)00459-5

upstream raw materials:

1-(2-chloroethyl)imidazolidin-2-one

Downstream raw materials:

1-[2-[4-[5-aminomethyl-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinon