1-[2-[4-[5-aminomethyl-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinon

Base Information

• Chemical Name: 1-[2-[4-[5-aminomethyl-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinon
• CAS No.: 330944-26-8
• Molecular Formula: C₂₅H₃₀FN₅O
• Molecular Weight: 435.545
• Mol file: 330944-26-8.mol

Synonyms:1-[2-[4-[5-aminomethyl-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinon

Chemical Property of 1-[2-[4-[5-aminomethyl-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinon

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2-[4-[5-aminomethyl-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinon

There total 2 articles about 1-[2-[4-[5-aminomethyl-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

1-(2-{4-[5-cyano-1-(4-fluorophenyl)-1H-indol-3-yl]-1,2,3,6-tetrahydropyridin-1-yl}ethyl)-2-imidazolidinone (138900-26-2) → 1-[2-[4-[5-aminomethyl-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinon (330944-26-8)

Guidance literature:

With hydrogen; platinum(IV) oxide; In acetic acid; at 20 ℃; for 5h; under 2206.52 Torr;

DOI:10.1016/S0968-0896(02)00459-5

Reference yield:

→ 1-[2-[4-[5-aminomethyl-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinon (330944-26-8)

Guidance literature:

Reference yield: 27.0%

acetyl chloride (75-36-5) + 1-[2-[4-[5-aminomethyl-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinon (330944-26-8) → N-(1-(4-fluoro-phenyl)-3-{1-[2-(2-oxo-imidazolidin-1-yl)-ethyl]-piperidin-4-yl}-1H-indol-5-ylmethyl)-acetamide

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/S0968-0896(02)00459-5

upstream raw materials:

1-(2-{4-[5-cyano-1-(4-fluorophenyl)-1H-indol-3-yl]-1,2,3,6-tetrahydropyridin-1-yl}ethyl)-2-imidazolidinone