(2R,3R,4R,5R,6R)-3,4,5,6-tetrakis(benzyloxy)-2-methylazepan-1-ol

Base Information

Chemical Name:(2R,3R,4R,5R,6R)-3,4,5,6-tetrakis(benzyloxy)-2-methylazepan-1-ol
CAS No.:1427017-06-8
Molecular Formula:C₃₅H₃₉NO₅
Molecular Weight:553.698
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R,4R,5R,6R)-3,4,5,6-tetrakis(benzyloxy)-2-methylazepan-1-ol

Chemical Property:

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Technology Process of (2R,3R,4R,5R,6R)-3,4,5,6-tetrakis(benzyloxy)-2-methylazepan-1-ol

There total 4 articles about (2R,3R,4R,5R,6R)-3,4,5,6-tetrakis(benzyloxy)-2-methylazepan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 917-64-6
methyl magnesium iodide

: 1427016-49-6
(3R,4R,5R,6R)-3,4,5,6-tetrakis(benzyloxy)-3,4,5,6-tetrahydro-7H-azepine 1-oxide

: 1427017-06-8
(2R,3R,4R,5R,6R)-3,4,5,6-tetrakis(benzyloxy)-2-methylazepan-1-ol

Guidance literature:: In tetrahydrofuran; diethyl ether; at 0 ℃; Inert atmosphere;
DOI:10.1021/jo400130p

Reference yield:

: 110578-68-2
2,3,4,5-tetrakis-benzyloxyhexane-1,6-diol

: 1427017-06-8
(2R,3R,4R,5R,6R)-3,4,5,6-tetrakis(benzyloxy)-2-methylazepan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0 - 20 °C

1.2: 24 h / Reflux

2.1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / Reflux

2.2: Reflux

3.1: oxone; sodium hydrogencarbonate; edetate disodium / tetrahydrofuran; acetonitrile / 3 h / 0 °C

4.1: tetrahydrofuran; diethyl ether / 0 °C / Inert atmosphere

With carbonochloridic acid 1-chloro-ethyl ester; oxone; edetate disodium; sodium hydrogencarbonate; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/jo400130p

Reference yield:

: 1427016-47-4
(3R,4R,5R,6R)-1-allyl-3,4,5,6-tetrakis(benzyloxy)azepane

: 1427017-06-8
(2R,3R,4R,5R,6R)-3,4,5,6-tetrakis(benzyloxy)-2-methylazepan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / Reflux

1.2: Reflux

2.1: oxone; sodium hydrogencarbonate; edetate disodium / tetrahydrofuran; acetonitrile / 3 h / 0 °C

3.1: tetrahydrofuran; diethyl ether / 0 °C / Inert atmosphere

With carbonochloridic acid 1-chloro-ethyl ester; oxone; edetate disodium; sodium hydrogencarbonate; In tetrahydrofuran; diethyl ether; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/jo400130p