(S)-4-2'-Hydroxy-1'-isopropyl-N-methylethylamino-1-phenylbutanone

Base Information

• Chemical Name: (S)-4-2'-Hydroxy-1'-isopropyl-N-methylethylamino-1-phenylbutanone
• CAS No.: 129087-37-2
• Molecular Formula: C₁₆H₂₅NO₂
• Molecular Weight: 263.38
• Mol file: 129087-37-2.mol

Synonyms:

Chemical Property of (S)-4-2'-Hydroxy-1'-isopropyl-N-methylethylamino-1-phenylbutanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-2'-Hydroxy-1'-isopropyl-N-methylethylamino-1-phenylbutanone

There total 4 articles about (S)-4-2'-Hydroxy-1'-isopropyl-N-methylethylamino-1-phenylbutanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-iodobutyrophenone (65488-05-3) → (S)-4-2'-Hydroxy-1'-isopropyl-N-methylethylamino-1-phenylbutanone (129087-37-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / p-toluenesulfonic acid / benzene / 5 h / Heating

2: 1) anhydr. Na₂CO₃, 2) 5percent HCl / 1) benzene, reflux, 2) room temp., 15 min

With hydrogenchloride; sodium carbonate; toluene-4-sulfonic acid; In benzene;

DOI:10.1248/cpb.38.1062

Reference yield:

(S)-N-2'-Hydroxy-1'-isopropylethyl-N-methyl-4-oxopentanamide (129087-51-0) → (S)-4-2'-Hydroxy-1'-isopropyl-N-methylethylamino-1-phenylbutanone (129087-37-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) ClTi(O-iso-C₃H₇)3 / 1) THF, toluene, room temp., 3 h, 2) room temp., 2 h

2: 68 percent / 10percent HCl / 0.33 h / Heating

3: 1) anhydr. Na₂CO₃, 2) 5percent HCl / 1) benzene, reflux, 2) room temp., 15 min

With triisopropoxytitanium(IV) chloride; hydrogenchloride; sodium carbonate;

DOI:10.1248/cpb.38.1062

Reference yield:

(1'S)-N-2'-Hydroxy-1'-isopropylethyl-N-methyl-4-hydroxy-4-phenylpentanamide (129087-52-1,129087-53-2) → (S)-4-2'-Hydroxy-1'-isopropyl-N-methylethylamino-1-phenylbutanone (129087-37-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / 10percent HCl / 0.33 h / Heating

2: 1) anhydr. Na₂CO₃, 2) 5percent HCl / 1) benzene, reflux, 2) room temp., 15 min

With hydrogenchloride; sodium carbonate;

DOI:10.1248/cpb.38.1062

upstream raw materials:

1,1-Ethylenedioxy-4-iodo-1-phenylbutane

(s)-N-methylvalinol

4-iodobutyrophenone

(S)-N-2'-Hydroxy-1'-isopropylethyl-N-methyl-4-oxopentanamide

Downstream raw materials:

(2R,1'S)-5-2'-Hydroxy-1'-isopropyl-N-methylethylamino-2-phenyl-2-pentanol

(2S,1'S)-5-2'-Hydroxy-1'-isopropyl-N-methylethylamino-2-phenyl-2-pentanol

(1'S)-5-2'-Hydroxy-1'-isopropyl-N-methylethylamino-2-phenyl-2-pentanol