1,1,1-trifluoro-2-(4-(2-(4-morpholinylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

Base Information

Chemical Name:1,1,1-trifluoro-2-(4-(2-(4-morpholinylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol
CAS No.:1361217-95-9
Molecular Formula:C₂₂H₂₈F₃N₃O₄S₂
Molecular Weight:519.609
Hs Code.:

Synonyms:

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Chemical Property of 1,1,1-trifluoro-2-(4-(2-(4-morpholinylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

Chemical Property:

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Technology Process of 1,1,1-trifluoro-2-(4-(2-(4-morpholinylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

There total 8 articles about 1,1,1-trifluoro-2-(4-(2-(4-morpholinylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106-37-6
1.4-dibromobenzene

: 1361217-95-9
1,1,1-trifluoro-2-(4-(2-(4-morpholinylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / diethyl ether; hexanes / 0.25 h / -78 °C

1.2: 0.5 h / -78 °C

2.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos / toluene / 16 h / 100 °C / sealed vessel

3.1: boron trichloride / dichloromethane / 1 h / -78 °C

3.2: 0 °C

4.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

5.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 1 h / 20 °C

With n-butyllithium; boron trichloride; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; Dess-Martin periodane; acetic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos; In hexanes; diethyl ether; dichloromethane; 1,2-dichloro-ethane; toluene;

Reference yield:

: 92018-20-7
2-benzyloxymethyl-piperazine

: 1361217-95-9
1,1,1-trifluoro-2-(4-(2-(4-morpholinylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 2 h / 0 °C

2.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos / toluene / 16 h / 100 °C / sealed vessel

3.1: boron trichloride / dichloromethane / 1 h / -78 °C

3.2: 0 °C

4.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

5.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 1 h / 20 °C

With boron trichloride; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; Dess-Martin periodane; acetic acid; triethylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos; In dichloromethane; 1,2-dichloro-ethane; toluene;

Reference yield:

: 122243-28-1
2‐(4‐bromophenyl)‐1,1,1‐trifluoropropan‐2‐ol

: 1361217-95-9
1,1,1-trifluoro-2-(4-(2-(4-morpholinylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos / toluene / 16 h / 100 °C / sealed vessel

2.1: boron trichloride / dichloromethane / 1 h / -78 °C

2.2: 0 °C

3.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

4.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 1 h / 20 °C

With boron trichloride; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; Dess-Martin periodane; acetic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos; In dichloromethane; 1,2-dichloro-ethane; toluene;