1-(3-amino-propyl)-piperidin-3-ol

Base Information

• Chemical Name: 1-(3-amino-propyl)-piperidin-3-ol
• CAS No.: 51387-96-3
• Molecular Formula: C₈H₁₈N₂O
• Molecular Weight: 158.244
• Mol file: 51387-96-3.mol

Synonyms:

Chemical Property of 1-(3-amino-propyl)-piperidin-3-ol

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

1-(3-Amino-propyl)-piperidin-3-ol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 1-(3-amino-propyl)-piperidin-3-ol

There total 2 articles about 1-(3-amino-propyl)-piperidin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acrylonitrile (107-13-1,25014-41-9) → 1-(3-amino-propyl)-piperidin-3-ol (51387-96-3)

Guidance literature:

Hydrieren des entstandenen (+-)-3-<3-Hydroxy-piperidino>-propionitrils an Raney-Kobalt in Triaethylamin bei 102grad und 125 at.;

DOI:10.1021/ja01535a051

Reference yield:

→ 1-(3-amino-propyl)-piperidin-3-ol (51387-96-3)

Guidance literature:

1-(2-Cyanethyl)-piperidin-3-ol, H2, Raney-Ni, PtO2, fl. NH3, MeOH;

Reference yield: 37.0%

1-(3-amino-propyl)-piperidin-3-ol (51387-96-3) + N-[(4-chlorophenyl)]-4-oxo-4-[oxy]butane amide (17722-52-0) → N1-(4-chlorophenyl)-N4-(3-(3-hydroxypiperidin-1-yl)propyl)succinamide (1375737-04-4)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In dichloromethane; for 6h;

DOI:10.1021/jm3002247

upstream raw materials:

acrylonitrile

Downstream raw materials:

1-{3-[2-(4-Iodo-phenylamino)-quinazolin-4-ylamino]-propyl}-piperidin-3-ol; hydrochloride

1-{3-[2-(4-Chloro-phenylamino)-quinazolin-4-ylamino]-propyl}-piperidin-3-ol; hydrochloride

N¹-(4-chlorophenyl)-N⁴-(3-(3-hydroxypiperidin-1-yl)propyl)succinamide