ethyl 4-methoxycyclohexanone-2-glyoxylate

Base Information

Chemical Name:ethyl 4-methoxycyclohexanone-2-glyoxylate
CAS No.:66800-24-6
Molecular Formula:C₁₁H₁₆O₅
Molecular Weight:228.245
Hs Code.:

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Chemical Property of ethyl 4-methoxycyclohexanone-2-glyoxylate

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Technology Process of ethyl 4-methoxycyclohexanone-2-glyoxylate

There total 2 articles about ethyl 4-methoxycyclohexanone-2-glyoxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 95-92-1
oxalic acid diethyl ester

: 66800-24-6
ethyl 4-methoxycyclohexanone-2-glyoxylate

Guidance literature:: With sodium ethanolate;
DOI:10.1039/jr9380000058

Reference yield:

: 66800-24-6
ethyl 4-methoxycyclohexanone-2-glyoxylate

Guidance literature:: Oxalsaeurediethylester, 4-Methoxy-cyclohexanon;

Reference yield:

: 66800-24-6
ethyl 4-methoxycyclohexanone-2-glyoxylate

: 78463-70-4
Toluene-4-sulfonic acid (2S,4aS,5S,13bR)-2,12-dimethoxy-6-oxo-2,4a,5,6,8,9-hexahydro-1H-indolo[7a,1-a]isoquinolin-5-yl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 2.) 85percent H₃PO₄ / 1.) benzene, reflux, 10 h; 2.) MeOH, reflux, 20 h

2: 19.84 g / NaBH₄ / methanol; H₂O / Ambient temperature

3: 10.23 g / concd. H₂SO₄ / 3 h / 40 - 50 °C

4: 54.6 percent / 20percent HCl / 20 h / Heating

5: 1.) NaNO₂, 10percent HCl; 2.) hypophosphorous acid / 1.) H₂O, 5-0 deg C; 2.) H₂O, 0 deg C, 24 h

6: 80 percent / p-toluenesulfonic acid / 1.5 h / Heating

7: 157 mg / m-chloroperbenzoic acid / CHCl₃ / 48 h / Ambient temperature

8: 1.) NaBH₄, diphenyldiselenide; 2.) 30percent H₂O₂ / 1.) EtOH, reflux, 2 h; 2.) EtOH, THF, 2 h

9: 96.4 mg / 6N HCl / 20 h / Heating

10: 102 mg / pyridine / 72 h

With pyridine; hydrogenchloride; sodium tetrahydroborate; phosphoric acid; sulfuric acid; diphenyl diselenide; dihydrogen peroxide; hypophosphorous acid; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; sodium nitrite; In methanol; chloroform; water;
DOI:10.1248/cpb.29.396