Technology Process of Toluene-4-sulfonic acid (2S,4aS,5S,13bR)-2,12-dimethoxy-6-oxo-2,4a,5,6,8,9-hexahydro-1H-indolo[7a,1-a]isoquinolin-5-yl ester
There total 11 articles about Toluene-4-sulfonic acid (2S,4aS,5S,13bR)-2,12-dimethoxy-6-oxo-2,4a,5,6,8,9-hexahydro-1H-indolo[7a,1-a]isoquinolin-5-yl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
-
![Toluene-4-sulfonic acid (2S,4aS,5S,13bR)-2,12-dimethoxy-6-oxo-2,4a,5,6,8,9-hexahydro-1H-indolo[7a,1-a]isoquinolin-5-yl ester](/Databaselist/images/loading.webp)
-
78463-70-4
Toluene-4-sulfonic acid (2S,4aS,5S,13bR)-2,12-dimethoxy-6-oxo-2,4a,5,6,8,9-hexahydro-1H-indolo[7a,1-a]isoquinolin-5-yl ester
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 2.) 85percent H3PO4 / 1.) benzene, reflux, 10 h; 2.) MeOH, reflux, 20 h
2: 19.84 g / NaBH4 / methanol; H2O / Ambient temperature
3: 10.23 g / concd. H2SO4 / 3 h / 40 - 50 °C
4: 54.6 percent / 20percent HCl / 20 h / Heating
5: 1.) NaNO2, 10percent HCl; 2.) hypophosphorous acid / 1.) H2O, 5-0 deg C; 2.) H2O, 0 deg C, 24 h
6: 80 percent / p-toluenesulfonic acid / 1.5 h / Heating
7: 157 mg / m-chloroperbenzoic acid / CHCl3 / 48 h / Ambient temperature
8: 1.) NaBH4, diphenyldiselenide; 2.) 30percent H2O2 / 1.) EtOH, reflux, 2 h; 2.) EtOH, THF, 2 h
9: 96.4 mg / 6N HCl / 20 h / Heating
10: 102 mg / pyridine / 72 h
With
pyridine; hydrogenchloride; sodium tetrahydroborate; phosphoric acid; sulfuric acid; diphenyl diselenide; dihydrogen peroxide; hypophosphorous acid; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; sodium nitrite;
In
methanol; chloroform; water;
DOI:10.1248/cpb.29.396
-
-
78463-70-4
Toluene-4-sulfonic acid (2S,4aS,5S,13bR)-2,12-dimethoxy-6-oxo-2,4a,5,6,8,9-hexahydro-1H-indolo[7a,1-a]isoquinolin-5-yl ester
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 2.) 85percent H3PO4 / 1.) benzene, reflux, 10 h; 2.) MeOH, reflux, 20 h
2: 19.84 g / NaBH4 / methanol; H2O / Ambient temperature
3: 10.23 g / concd. H2SO4 / 3 h / 40 - 50 °C
4: 54.6 percent / 20percent HCl / 20 h / Heating
5: 1.) NaNO2, 10percent HCl; 2.) hypophosphorous acid / 1.) H2O, 5-0 deg C; 2.) H2O, 0 deg C, 24 h
6: 80 percent / p-toluenesulfonic acid / 1.5 h / Heating
7: 157 mg / m-chloroperbenzoic acid / CHCl3 / 48 h / Ambient temperature
8: 1.) NaBH4, diphenyldiselenide; 2.) 30percent H2O2 / 1.) EtOH, reflux, 2 h; 2.) EtOH, THF, 2 h
9: 96.4 mg / 6N HCl / 20 h / Heating
10: 102 mg / pyridine / 72 h
With
pyridine; hydrogenchloride; sodium tetrahydroborate; phosphoric acid; sulfuric acid; diphenyl diselenide; dihydrogen peroxide; hypophosphorous acid; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; sodium nitrite;
In
methanol; chloroform; water;
DOI:10.1248/cpb.29.396
-
-
78463-70-4
Toluene-4-sulfonic acid (2S,4aS,5S,13bR)-2,12-dimethoxy-6-oxo-2,4a,5,6,8,9-hexahydro-1H-indolo[7a,1-a]isoquinolin-5-yl ester
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 80 percent / p-toluenesulfonic acid / 1.5 h / Heating
2: 157 mg / m-chloroperbenzoic acid / CHCl3 / 48 h / Ambient temperature
3: 1.) NaBH4, diphenyldiselenide; 2.) 30percent H2O2 / 1.) EtOH, reflux, 2 h; 2.) EtOH, THF, 2 h
4: 96.4 mg / 6N HCl / 20 h / Heating
5: 102 mg / pyridine / 72 h
With
pyridine; hydrogenchloride; sodium tetrahydroborate; diphenyl diselenide; dihydrogen peroxide; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid;
In
chloroform;
DOI:10.1248/cpb.29.396
