spiroindane

Base Information

Chemical Name:spiroindane
CAS No.:87897-07-2
Molecular Formula:C₂₄H₂₇NO₃
Molecular Weight:377.483
Hs Code.:

spiro<cyclohex-2-en-4-one-1,1'-(3'-methylbenzylamino)-6',7'-dimethoxy>indane

Synonyms:

Suppliers and Price of spiroindane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of spiroindane

Chemical Property:

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Technology Process of spiroindane

There total 8 articles about spiroindane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 78-94-4,25038-87-3
methyl vinyl ketone

: 87896-95-5
3-(Benzyl-methyl-amino)-6,7-dimethoxy-indan-1-carbaldehyde

: 87897-07-2,87897-08-3
spiroindane

Guidance literature:: With N-benzyl-trimethylammonium hydroxide; In methanol; tert-butyl alcohol; for 5h; Ambient temperature;
DOI:10.1016/S0040-4020(01)82450-9

Reference yield:

: 57441-74-4
6,7-dimethoxy-2,3-dihydro-1H-inden-1-one

: 87897-07-2,87897-08-3
spiroindane

Guidance literature:: Multi-step reaction with 8 steps

1: 70 percent / 5,5-dibromo-2,2-dimethyl-4,6-dioxo-1,3-dioxane / CCl₄ / 1) room temp. 2) 75 deg C, 4 h

2: p-toluenesulfonic acid / toluene / 8 h / Heating

3: 75 percent / t-BuOK, t-BuOH / 3 h / 90 °C

4: 100 percent / silica gel, HCl / 0.5 h / Ambient temperature

5: 90 percent / CCl₄ / 18 h / 60 °C

6: 1)NaH / 1) DMSO, 30 min 2) 20 h, room temp.

7: 85 percent / methanesulfonic acid / 4 h / 90 °C

8: 25 percent / Triton B / 2-methyl-propan-2-ol; methanol / 5 h / Ambient temperature

With hydrogenchloride; methanesulfonic acid; 2,2-dimethyl-5,5-dibromo-1,3-dioxane-4,6-dione; potassium tert-butylate; silica gel; N-benzyl-trimethylammonium hydroxide; sodium hydride; toluene-4-sulfonic acid; tert-butyl alcohol; In methanol; tetrachloromethane; toluene; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)82450-9

Reference yield:

: 87896-91-1
6,7-dimethoxyindenone

: 87897-07-2,87897-08-3
spiroindane

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / CCl₄ / 18 h / 60 °C

2: 1)NaH / 1) DMSO, 30 min 2) 20 h, room temp.

3: 85 percent / methanesulfonic acid / 4 h / 90 °C

4: 25 percent / Triton B / 2-methyl-propan-2-ol; methanol / 5 h / Ambient temperature

With methanesulfonic acid; N-benzyl-trimethylammonium hydroxide; sodium hydride; In methanol; tetrachloromethane; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)82450-9