(5-chloro-2-{2-(2,4-difluorophenoxy)-2-[4-(piperidine-1-sulfonyl)phenyl]acetylamino}thiazol-4-yl)acetic acid

Base Information

Chemical Name:(5-chloro-2-{2-(2,4-difluorophenoxy)-2-[4-(piperidine-1-sulfonyl)phenyl]acetylamino}thiazol-4-yl)acetic acid
CAS No.:1328985-68-7
Molecular Formula:C₂₄H₂₂ClF₂N₃O₆S₂
Molecular Weight:586.037
Hs Code.:

Synonyms:

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Chemical Property of (5-chloro-2-{2-(2,4-difluorophenoxy)-2-[4-(piperidine-1-sulfonyl)phenyl]acetylamino}thiazol-4-yl)acetic acid

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Technology Process of (5-chloro-2-{2-(2,4-difluorophenoxy)-2-[4-(piperidine-1-sulfonyl)phenyl]acetylamino}thiazol-4-yl)acetic acid

There total 8 articles about (5-chloro-2-{2-(2,4-difluorophenoxy)-2-[4-(piperidine-1-sulfonyl)phenyl]acetylamino}thiazol-4-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1328984-14-0,1328991-41-8,1328991-43-0
ethyl 2-[5-chloro-2-[[2-(2,4-difluorophenoxy)-2-[4-(1-piperidylsulfonyl)phenyl]acetyl]amino]thiazol-4-yl]acetate

: 1328985-68-7,1328987-78-5,1328987-81-0
(5-chloro-2-{2-(2,4-difluorophenoxy)-2-[4-(piperidine-1-sulfonyl)phenyl]acetylamino}thiazol-4-yl)acetic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1016/j.ejmech.2017.03.042

Reference yield:

: methyl 2-bromo-2-[4-(1-piperidylsulfonyl)phenyl]acetate

: 1328985-68-7,1328987-78-5,1328987-81-0
(5-chloro-2-{2-(2,4-difluorophenoxy)-2-[4-(piperidine-1-sulfonyl)phenyl]acetylamino}thiazol-4-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / acetonitrile / 3.5 h / 25 °C / Inert atmosphere

2: lithium hydroxide / tetrahydrofuran; methanol; water / 18 h / 20 °C / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 18 h / 20 °C / Cooling with ice; Inert atmosphere

4: lithium hydroxide / tetrahydrofuran; methanol; water / 18 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1016/j.ejmech.2017.03.042

Reference yield:

: 39161-84-7
4-mercaptophenylacetic acid

: 1328985-68-7,1328987-78-5,1328987-81-0
(5-chloro-2-{2-(2,4-difluorophenoxy)-2-[4-(piperidine-1-sulfonyl)phenyl]acetylamino}thiazol-4-yl)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / methanol / 24 h / 20 °C / Inert atmosphere

2.1: potassium nitrate; chloro-trimethyl-silane / dichloromethane / 50 °C / Sealed tube; Inert atmosphere

3.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 48 h / Reflux; Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: caesium carbonate / acetonitrile / 3.5 h / 25 °C / Inert atmosphere

5.1: lithium hydroxide / tetrahydrofuran; methanol; water / 18 h / 20 °C / Inert atmosphere

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 18 h / 20 °C / Cooling with ice; Inert atmosphere

7.1: lithium hydroxide / tetrahydrofuran; methanol; water / 18 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; N-Bromosuccinimide; chloro-trimethyl-silane; sulfuric acid; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; lithium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1016/j.ejmech.2017.03.042