di-t-butyl ester of 4-(t-BOC-L-leucyl)methotrexate

Base Information

Chemical Name:di-t-butyl ester of 4-(t-BOC-L-leucyl)methotrexate
CAS No.:125507-12-2
Molecular Formula:C₃₉H₅₇N₉O₈
Molecular Weight:779.937
Hs Code.:

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Chemical Property of di-t-butyl ester of 4-(t-BOC-L-leucyl)methotrexate

Chemical Property:

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Technology Process of di-t-butyl ester of 4-(t-BOC-L-leucyl)methotrexate

There total 3 articles about di-t-butyl ester of 4-(t-BOC-L-leucyl)methotrexate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3350-19-4
(tert-butoxycarbonyl)-L-leucine p-nitrobenzylester

: 86669-33-2
methotrexate di-t-butyl ester

: 125507-12-2
di-t-butyl ester of 4-(t-BOC-L-leucyl)methotrexate

: 125507-10-0
di-t-butyl ester of 2-(t-BOC-L-leucyl)methotrexate

: 125507-14-4
di-t-butyl ester of 2,4-di(t-BOC-L-leucyl)methotrexate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 70 - 75 ℃; for 4h;

Reference yield:

: 16874-06-9
di-tert-butyl L-glutamate

: 125507-12-2
di-t-butyl ester of 4-(t-BOC-L-leucyl)methotrexate

Guidance literature:: Multi-step reaction with 2 steps

1: method described in literature

2: dicyclohexylcarbodiimide / ethyl acetate / 7 h / 45 °C

With dicyclohexyl-carbodiimide; In ethyl acetate;

Reference yield:

: p-methylaminobenzoate

: 125507-12-2
di-t-butyl ester of 4-(t-BOC-L-leucyl)methotrexate

Guidance literature:: Multi-step reaction with 2 steps

1: method described in literature

2: dicyclohexylcarbodiimide / ethyl acetate / 7 h / 45 °C

With dicyclohexyl-carbodiimide; In ethyl acetate;