C₂₁H₂₈F₂N₂O₅

Base Information

Chemical Name:C₂₁H₂₈F₂N₂O₅
CAS No.:1350901-09-5
Molecular Formula:C₂₁H₂₈F₂N₂O₅
Molecular Weight:426.461
Hs Code.:

C<sub>21</sub>H<sub>28</sub>F<sub>2</sub>N<sub>2</sub>O<sub>5</sub>

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₁H₂₈F₂N₂O₅

Chemical Property:

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Technology Process of C₂₁H₂₈F₂N₂O₅

There total 6 articles about C₂₁H₂₈F₂N₂O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-75-1
pyrrolidine

: 1345724-25-5
N-benzyloxycarbonyl-4,4-difluoro-L-glutamic acid 5-tert-butyl ester

: 1350901-09-5
C₂₁H₂₈F₂N₂O₅

Guidance literature:: With ethylene dichloride hydrochloride; 1-butanol+water; In dichloromethane; at 20 ℃;
DOI:10.1021/jo2018679

Reference yield:

: 1345724-21-1
5-tert-butyl 1-methyl N-benzyloxycarbonyl-4,4-difluoroglutamate

: 1350901-09-5
C₂₁H₂₈F₂N₂O₅

Guidance literature:: Multi-step reaction with 2 steps

1: subtilisin Carlsberg from Bacillus licheniformis / dimethyl sulfoxide / 13 h / 23 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

2: ethylene dichloride hydrochloride; 1-butanol+water / dichloromethane / 20 °C

With ethylene dichloride hydrochloride; 1-butanol+water; subtilisin Carlsberg from Bacillus licheniformis; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo2018679

Reference yield:

: C₇H₁₁F₂NO₄*ClH

: 1350901-09-5
C₂₁H₂₈F₂N₂O₅

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydrogencarbonate / water / 0 - 23 °C

2: methanol; hexane; toluene / 20 °C

3: lithium hydroxide / methanol; water / 0.03 h / 0 °C

4: N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate / N,N-dimethyl acetamide / 18 h / 55 °C

5: subtilisin Carlsberg from Bacillus licheniformis / dimethyl sulfoxide / 13 h / 23 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

6: ethylene dichloride hydrochloride; 1-butanol+water / dichloromethane / 20 °C

With ethylene dichloride hydrochloride; 1-butanol+water; N-benzyl-N,N,N-triethylammonium chloride; sodium hydrogencarbonate; potassium carbonate; lithium hydroxide; subtilisin Carlsberg from Bacillus licheniformis; In methanol; hexane; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; toluene;
DOI:10.1021/jo2018679