4-Fluoro-2-nitrophenyl triflate, 5-Fluoro-2-{[(trifluoromethyl)sulphonyl]oxy}nitrobenzene

Base Information

• Chemical Name: 4-Fluoro-2-nitrophenyl triflate, 5-Fluoro-2-{[(trifluoromethyl)sulphonyl]oxy}nitrobenzene
• CAS No.: 722536-28-9
• Molecular Formula: C₇H₃F₄NO₅S
• Molecular Weight: 289.164
• Hs Code.: 2930909899
• Mol file: 722536-28-9.mol

Synonyms:

Chemical Property of 4-Fluoro-2-nitrophenyl triflate, 5-Fluoro-2-{[(trifluoromethyl)sulphonyl]oxy}nitrobenzene

Chemical Property:

Purity/Quality:

4-Fluoro-2-nitrophenyl trifluoromethanesulfonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Fluoro-2-nitrophenyl triflate, 5-Fluoro-2-{[(trifluoromethyl)sulphonyl]oxy}nitrobenzene

There total 2 articles about 4-Fluoro-2-nitrophenyl triflate, 5-Fluoro-2-{[(trifluoromethyl)sulphonyl]oxy}nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trifluoromethylsulfonic anhydride (358-23-6) + 2-nitro-4-fluorophenol (394-33-2) → C7H3F4NO5S (722536-28-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1016/j.bmcl.2011.09.018

Reference yield:

4-Fluorophenol (371-41-5) → C7H3F4NO5S (722536-28-9)

Guidance literature:

Multi-step reaction with 2 steps

1: nitronium tetrafluoborate / acetonitrile / 1 h / 0 °C

2: triethylamine / dichloromethane / 2 h / 0 °C

With nitronium tetrafluoborate; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2011.09.018

Reference yield:

6-(5-fluoro-2-methoxyphenyl)-6-methyl-4-trifluoromethylhept-1-yn-4-ol (609849-80-1) + C7H3F4NO5S (722536-28-9) → C22H20F5NO4

Guidance literature:

With copper(l) iodide; dichlorobis(tri-O-tolylphosphine)palladium; triethylamine; In acetonitrile; at 20 ℃;

DOI:10.1016/j.bmcl.2011.09.018

upstream raw materials:

4-Fluorophenol

trifluoromethylsulfonic anhydride

2-nitro-4-fluorophenol

Downstream raw materials:

C₂₂H₂₂F₅NO₂

Refernces